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Start Over Author "Dai, Zhengxi" Journal oncoimmunology
2 results on '"Dai, Zhengxi"'

1. Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells

Author

Wen, Xiangshu, Xiong, Ran, Dai, Zhengxi, Kim, Seil, Lawrenczyk, Agnieszka, and Yuan, Weiming

Abstract

The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing mice with respect to the CD1d/NKT antigen presentation system will provide a tool to identify novel lipids that exert antineoplastic functions by targeting NKT cells before the initiation of costly and lengthy clinical trials.

Published
2013
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