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Your search keyword '"Kishibe, Kan"' showing total 3 results
Start Over Author "Kishibe, Kan" Journal oncoimmunology
3 results on '"Kishibe, Kan"'

1. Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma

Author

Kono, Michihisa, primary, Komatsuda, Hiroki, additional, Yamaki, Hidekiyo, additional, Kumai, Takumi, additional, Hayashi, Ryusuke, additional, Wakisaka, Risa, additional, Nagato, Toshihiro, additional, Ohkuri, Takayuki, additional, Kosaka, Akemi, additional, Ohara, Kenzo, additional, Kishibe, Kan, additional, Takahara, Miki, additional, Katada, Akihiro, additional, Hayashi, Tatsuya, additional, Kobayashi, Hiroya, additional, and Harabuchi, Yasuaki, additional

Published
2022
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2. Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma

Author

Hayashi, Ryusuke, primary, Nagato, Toshihiro, additional, Kumai, Takumi, additional, Ohara, Kenzo, additional, Ohara, Mizuho, additional, Ohkuri, Takayuki, additional, Hirata-Nozaki, Yui, additional, Harabuchi, Shohei, additional, Kosaka, Akemi, additional, Nagata, Marino, additional, Yajima, Yuki, additional, Yasuda, Syunsuke, additional, Oikawa, Kensuke, additional, Kono, Michihisa, additional, Kishibe, Kan, additional, Takahara, Miki, additional, Katada, Akihiro, additional, Hayashi, Tatsuya, additional, Celis, Esteban, additional, Harabuchi, Yasuaki, additional, and Kobayashi, Hiroya, additional

Published
2020
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3. Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma

Author

Hayashi, Ryusuke, Nagato, Toshihiro, Kumai, Takumi, Ohara, Kenzo, Ohara, Mizuho, Ohkuri, Takayuki, Hirata-Nozaki, Yui, Harabuchi, Shohei, Kosaka, Akemi, Nagata, Marino, Yajima, Yuki, Yasuda, Syunsuke, Oikawa, Kensuke, Kono, Michihisa, Kishibe, Kan, Takahara, Miki, Katada, Akihiro, Hayashi, Tatsuya, Celis, Esteban, Harabuchi, Yasuaki, and Kobayashi, Hiroya

Abstract

ABSTRACTPlacenta-specific 1 (PLAC1) is expressed primarily in placental trophoblasts but not in normal tissues and is a targetable candidate for cancer immunotherapy because it is a cancer testis antigen known to be up-regulated in various tumors. Although peptide epitopes capable of stimulating CD8 T cells have been previously described, there have been no reports of PLAC1 CD4 helper T lymphocyte (HTL) epitopes and the expression of this antigen in head and neck squamous cell carcinoma (HNSCC). Here, we show that PLAC1 is highly expressed in 74.5% of oropharyngeal and 51.9% of oral cavity tumors from HNSCC patients and in several HNSCC established cell lines. We also identified an HTL peptide epitope (PLAC131-50) capable of eliciting effective antigen-specific and tumor-reactive T cell responses. Notably, this peptide behaves as a promiscuous epitope capable of stimulating T cells in the context of more than one human leukocyte antigen (HLA)-DR allele and induces PLAC1-specific CD4 T cells that kill PLAC1-positive HNSCC cell lines in an HLA-DR-restricted manner. Furthermore, T-cells reactive to PLAC131-50peptide were detected in the peripheral blood of HNSCC patients. These findings suggest that PLAC1 represents a potential target antigen for HTL based immunotherapy in HNSCC.

Published
2021
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