Search

Your search keyword '"Sampson, John H"' showing total 11 results
Start Over Author "Sampson, John H" Journal oncoimmunology
11 results on '"Sampson, John H"'

1. CD27 stimulation unveils the efficacy of linked class I/II peptide vaccines in poorly immunogenic tumors by orchestrating a coordinated CD4/CD8 T cell response

Author

Riccione, Katherine A., primary, He, Li-Zhen, additional, Fecci, Peter E., additional, Norberg, Pamela K., additional, Suryadevara, Carter M., additional, Swartz, Adam, additional, Healy, Patrick, additional, Reap, Elizabeth, additional, Keler, Tibor, additional, Li, Qi-Jing, additional, Congdon, Kendra L., additional, Sanchez-Perez, Luis, additional, and Sampson, John H., additional

Published
2018
Full Text
View/download PDF

2. Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma

Author

Suryadevara, Carter M., primary, Desai, Rupen, additional, Abel, Melissa L., additional, Riccione, Katherine A., additional, Batich, Kristen A., additional, Shen, Steven H., additional, Chongsathidkiet, Pakawat, additional, Gedeon, Patrick C., additional, Elsamadicy, Aladine A., additional, Snyder, David J., additional, Herndon, James E., additional, Healy, Patrick, additional, Archer, Gary E., additional, Choi, Bryan D., additional, Fecci, Peter E., additional, Sampson, John H., additional, and Sanchez-Perez, Luis, additional

Published
2018
Full Text
View/download PDF

4. Are BiTEs the “missing link” in cancer therapy?

Author

Suryadevara, Carter M, primary, Gedeon, Patrick C, additional, Sanchez-Perez, Luis, additional, Verla, Terence, additional, Alvarez-Breckenridge, Christopher, additional, Choi, Bryan D, additional, Fecci, Peter E, additional, and Sampson, John H, additional

Published
2015
Full Text
View/download PDF

11. Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles.

Author

Sayour, Elias J., De Leon, Gabriel, Pham, Christina, Grippin, Adam, Kemeny, Hanna, Chua, Joshua, Huang, Jianping, Sampson, John H., Sanchez-Perez, Luis, Flores, Catherine, and Mitchell, Duane A.

Subjects
ANTIGEN presenting cells, DENDRITIC cells, RNA, TUMORS
Abstract

While RNA-pulsed dendritic cell (DC) vaccines have shown promise, the advancement of cellular therapeutics is fraught with developmental challenges. To circumvent the challenges of cellular immunotherapeutics, we developed clinically translatable nanoliposomes that can be combined with tumor-derived RNA to generate personalized tumor RNA-nanoparticles (NPs) with considerable scale-up capacity. RNA-NPs bypass MHC restriction, are amenable to central distribution, and can provide near immediate immune induction. We screened commercially available nanoliposomal preparations and identified the cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) as an efficient mRNA courier to antigen-presenting cells (APCs). When administered intravenously, RNA-NPs mediate systemic activation of APCs in reticuloendothelial organs such as the spleen, liver, and bone marrow. RNA-NPs increase percent expression of MHC class I/II, B7 co-stimulatory molecules, and maturation markers on APCs (all vital for T-cell activation). RNA-NPs also increase activation markers on tumor APCs and elicit potent expansion of antigen-specific T-cells superior to peptide vaccines formulated in complete Freund's adjuvant. We demonstrate that both model antigen-encoding and physiologically-relevant tumor-derived RNA-NPs expand potent antitumor T-cell immunity. RNA-NPs were shown to induce antitumor efficacy in a vaccine model and functioned as a suitable alternative to DCs in a stringent cellular immunotherapy model for a radiation/temozolomide resistant invasive murine high-grade glioma. Although cancer vaccines have suffered from weak immunogenicity, we have advanced a RNA-NP formulation that systemically activates host APCs precipitating activated T-cell frequencies necessary to engender antitumor efficacy. RNA-NPs can thus be harnessed as a more feasible and effective immunotherapy to re-program host-immunity. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results