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1. In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma.

Author

Koster BD, de Jong TD, van den Hout MFCM, Sluijter BJR, Vuylsteke RJCLM, Molenkamp BG, Vosslamber S, van den Tol MP, van den Eertwegh AJM, and de Gruijl TD

Subjects
Dendritic Cells, Female, Humans, Male, Sex Factors, Granulocyte-Macrophage Colony-Stimulating Factor therapeutic use, Melanoma drug therapy
Abstract

Whereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we assessed the effects of local immune modulation in early-stage melanoma with CpG-B alone or with GM-CSF. Here we discuss the added value of GM-CSF and show sex-related differences., (© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.)

Published
2019
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