1. Pressurized Intraperitoneal Aerosol Chemotherapy-Related Clinical Trials in the Treatment of Peritoneal Metastases.
- Author
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Ukegjini, Kristjan, Putora, Paul Martin, Guidi, Marisa, Süveg, Krisztian, Cihoric, Nikola, Widmann, Bernhard, and Steffen, Thomas
- Subjects
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DRUG efficacy , *CLINICAL trials , *ACADEMIC medical centers , *AEROSOLS , *CANCER chemotherapy , *DOXORUBICIN , *METASTASIS , *INTRAPERITONEAL injections , *PERITONEUM tumors , *CANCER patients , *FLUOROURACIL , *CISPLATIN , *DOCETAXEL , *QUALITY of life , *INHALATION administration , *OXALIPLATIN , *PACLITAXEL , *LONGITUDINAL method - Abstract
Introduction: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a treatment option for patients with peritoneal metastases. We evaluated the current status of ongoing prospective clinical trials investigating PIPAC to provide an overview and predict trends in this field. Methods: All 367,494 records of clinical trials registered at ClinicalTrials.gov were searched for trials dealing with PIPAC. Active or unpublished trials were further analyzed. Results: In total, 22 clinical trials were identified and selected for further analyses. Most trials had a single-arm design and were phase I or II. No phase III trials were registered. Academic centers were recorded as primary sponsors in the majority of trials (63.6%). Every year, between 2 and 5 new trials were initiated. In 17 trials (81.8%), PIPAC was used in a palliative setting only, 2 trials performed PIPAC in a neoadjuvant setting, and 2 trials performed PIPAC in an adjuvant setting. Six different drugs (doxorubicin, cisplatin, oxaliplatin, nab-paclitaxel, 5-fluorouracil, and docetaxel) were used in these clinical trials. Most trials investigated the efficacy (n = 15) or safety (n = 7) of PIPAC therapies. Conclusions: The results of ongoing clinical trials will bring specific information on indications for PIPAC as well as the impact of PIPAC on quality of life and overall survival. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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