1. Clinical and prognostic significance of MYH11 in lung cancer
- Author
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He‑Yun Tao, Xi Zou, Shen‑Lin Liu, Meng‑Jun Xu, Wei Sun, Jian Wu, Meng‑Jun Nie, and Xiao‑Ting Pan
- Subjects
0301 basic medicine ,Cancer Research ,Oncogene ,business.industry ,Contractile fiber part ,Cancer ,Actin cytoskeleton ,medicine.disease ,Molecular medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Myosin ,medicine ,MYH11 ,Cancer research ,business ,Lung cancer - Abstract
Myosin heavy chain 11 (MYH11), encoded by the MYH11 gene, is a protein that participates in muscle contraction through the hydrolysis of adenosine triphosphate. Although previous studies have demonstrated that MYH11 gene expression levels are downregulated in several types of cancer, its expression levels have rarely been investigated in lung cancer. The present study aimed to explore the clinical significance and prognostic value of MYH11 expression levels in lung cancer and to further study the underlying molecular mechanisms of the function of this gene. The Oncomine database showed that the MYH11 expression levels were decreased in lung cancer compared with those noted in the normal lung tissue (P
- Published
- 2020