1. Five extracellular matrix-associated genes upregulated in oral tongue squamous cell carcinoma: An integrated bioinformatics analysis
- Author
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Jiesen Li, Jun Peng, Liya Liu, Zhongxin Chen, Xiaoyan Hu, Bangyan Wang, Pingping Zhong, Yichao Cai, Youqin Chen, Aling Shen, and Jie Lin
- Subjects
0301 basic medicine ,Cancer Research ,Candidate gene ,bioinformatics analysis ,Microarray ,Oncogene ,Cell ,Articles ,Cell cycle ,Biology ,medicine.disease ,head and neck squamous cell carcinoma ,Head and neck squamous-cell carcinoma ,Molecular medicine ,differentially expressed gene ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Oncology ,oral tongue squamous cell carcinoma ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,Extracellular matrix disassembly - Abstract
Despite advancements in treatment regimens, the mortality rate of patients with oral tongue squamous cell carcinoma (OTSCC) is high. In addition, the signaling pathways and oncoproteins involved in OTSCC progression remain largely unknown. Therefore, the aim of the present study was to identify specific prognostic marker for patients at a high risk of developing OTSCC. The present study used four original microarray datasets to identify the key candidate genes involved in OTSCC pathogenesis. Expression profiles of 93 OTSCC tissues and 76 normal tissues from GSE9844, GSE13601, GSE31056 and GSE75538 datasets were investigated. Differentially expressed genes (DEGs) were determined, and gene ontology enrichment and gene interactions were analyzed. The four GSE datasets reported five upregulated and six downregulated DEGs. Five upregulated genes (matrix metalloproteinase 1, 3, 10 and 12 and laminin subunit gamma 2) were localized in the extracellular region of cells and were associated with extracellular matrix disassembly. Furthermore, analysis for The Cancer Genome Atlas database revealed that the aforementioned five upregulated genes were also highly expressed in OTSCC and head and neck squamous cell carcinoma tissues. These results demonstrated that the five upregulated genes may be considered as potential prognostic biomarkers of OTSCC and may serve at understanding OTSCC progression. Upregulated DEGs may therefore represent valuable therapeutic targets to prevent or control OTSCC pathogenesis.
- Published
- 2019