1. The association between aquaporin-1 expression, microvessel density and the clinicopathological features of hepatocellular carcinoma
- Author
-
Xin‑Rui Liu, Hu Xia, Rong Shi, Jun Zeng, Li‑Min Luo, and Min Wei
- Subjects
0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,aquaporin-1 ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Stage (cooking) ,Oncogene ,Cancer ,Articles ,hepatocellular carcinoma ,Cell cycle ,intratumoral microvessel density ,medicine.disease ,Molecular medicine ,digestive system diseases ,030104 developmental biology ,Tumor progression ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,immunohistochemistry ,Immunohistochemistry ,prognosis - Abstract
The present study aimed to evaluate the effects of aquaporin-1 (AQP1) level and intratumoral microvessel density (IMD) on the clinicopathological features of patients with hepatocellular carcinoma (HCC). The AQP1 expression levels, IMD and AQP1/IMD ratios in patients with HCC were measured using a semi-quantitative immunohistochemical technique. The association between these features and clinicopathological variables were evaluated. The prognostic impact of AQP1 and IMD on overall survival (OS), and 5-year disease-free survival (DFS) of HCC patients was investigated retrospectively. P
- Published
- 2017