Search

Your search keyword '"Han, Sang-Bae"' showing total 16 results
Start Over Author "Han, Sang-Bae" Journal oncotarget
16 results on '"Han, Sang-Bae"'

1. A small molecule, (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol suppresses tumor growth via inhibition of IkappaB kinase β in colorectal cancer in vivo and in vitro

Author

Zheng, Jie, primary, Park, Mi Hee, additional, Lee, Hee Pom, additional, Hyun, Byung Kook, additional, Chun, Hyung Ok, additional, Jung, Sung Hee, additional, Seo, Hyun Ok, additional, Ham, Young Wan, additional, Han, Sang-Bae, additional, and Hong, Jin Tae, additional

Published
2017
Full Text
View/download PDF

2. KRICT-9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer’s disease models

Author

Lee, Do Yeon, primary, Hwang, Chul Ju, additional, Choi, Ji Yeon, additional, Park, Mi Hee, additional, Song, Min Ji, additional, Oh, Ki Wan, additional, Han, Sang Bae, additional, Park, Woo Kyu, additional, Cho, Hee Yeong, additional, Cho, Sung Yun, additional, Park, Hye Byn, additional, Song, Min Jong, additional, and Hong, Jin Tae, additional

Published
2017
Full Text
View/download PDF

6. Inhibitory effect of thiacremonone on MPTP-induced dopaminergic neurodegeneration through inhibition of p38 activation

Author

Hwang, Chul Ju, primary, Lee, Hee Pom, additional, Choi, Dong-Young, additional, Jeong, Heon Sang, additional, Kim, Tae Hoon, additional, Lee, Tae Hyung, additional, Kim, Young Min, additional, Moon, Dae Bong, additional, Park, Sung Sik, additional, Kim, Sun Young, additional, Oh, Ki-Wan, additional, Hwang, Dae Yeon, additional, Han, Sang-Bae, additional, Lee, Hwa-Jeong, additional, and Hong, Jin Tae, additional

Published
2016
Full Text
View/download PDF

9. CCR5 deficiency accelerates lipopolysaccharide-induced astrogliosis, amyloid-beta deposit and impaired memory function

Author

Hwang, Chul Ju, primary, Park, Mi Hee, additional, Hwang, Jae Yeon, additional, Kim, Ju Hwan, additional, Yun, Na Young, additional, Oh, Sang Yeon, additional, Song, Ju Kyung, additional, Seo, Hyun Ok, additional, Kim, Yun-Bae, additional, Hwang, Dae Yeon, additional, Oh, Ki-Wan, additional, Han, Sang-Bae, additional, and Hong, Jin Tae, additional

Published
2016
Full Text
View/download PDF

14. Bee venom inhibits growth of human cervical tumors in mice

Author

Lee, Hye Lim, primary, Park, Sang Ho, additional, Kim, Tae Myoung, additional, Jung, Yu Yeon, additional, Park, Mi Hee, additional, Oh, Sang Hyun, additional, Yun, Hye Seok, additional, Jun, Hyung Ok, additional, Yoo, Hwan Soo, additional, Han, Sang-Bae, additional, Lee, Ung Soo, additional, Yoon, Joo Hee, additional, Song, Min Jong, additional, and Hong, Jin Tae, additional

Published
2015
Full Text
View/download PDF

15. Efficient lytic induction of kaposi's sarcoma-associated herpesvirus (KSHV) by the anthracyclines

Author

Kang, Hyunju, primary, Song, Jaehyung, additional, Choi, Kwangman, additional, Kim, Hyeongki, additional, Choi, Miri, additional, Lee, So-Young, additional, Kim, Chonsaeng, additional, Lee, Sang Jun, additional, Song, Moon Jung, additional, Kang, Hyojeung, additional, Back, Sung Hoon, additional, Han, Sang-Bae, additional, and Cho, Sungchan, additional

Published
2014
Full Text
View/download PDF

16. Inhibitory effect of ethanol extract of Nannochloropsis oceanica on lipopolysaccharide-induced neuroinflammation, oxidative stress, amyloidogenesis and memory impairment.

Author

Choi JY, Hwang CJ, Lee HP, Kim HS, Han SB, and Hong JT

Subjects
Amyloid Precursor Protein Secretases metabolism, Amyloidosis drug therapy, Amyloidosis etiology, Amyloidosis physiopathology, Animals, Astrocytes metabolism, Biological Products chemistry, Cell Line, Disease Models, Animal, Gene Expression, Genes, Reporter, Lipopolysaccharides adverse effects, Male, Memory Disorders drug therapy, Memory Disorders etiology, Memory Disorders physiopathology, Mice, Microglia metabolism, Nitric Oxide metabolism, Oxidation-Reduction drug effects, Reactive Oxygen Species metabolism, Amyloidosis metabolism, Biological Products pharmacology, Memory Disorders metabolism, Oxidative Stress drug effects, Stramenopiles chemistry
Abstract

Oxidative stress and neuroinflammation is implicated in the pathogenesis and development of Alzheimer's disease (AD). Here, we investigated the suppressive possibility of ethanol extract of Nannochloropsis oceanica (N. oceanica) on memory deficiency along with the fundamental mechanisms in lipopolysaccharide (LPS)-treated mice model. Among several extracts of 32 marine microalgae, ethanol extract of N. oceanica showed the most significant inhibitory effect on nitric oxide (NO) generation, NF-κB activity and β-secretase activity in cultured BV-2 cells, neuronal cells and Raw 264.7 cells. Ethanol extract of N. oceanica (50, 100 mg/kg) also ameliorated LPS (250 μg/kg)-induced memory impairment. We also found that ethanol extract of N. oceanica inhibited the LPS-induced expression of iNOS and COX-2. Furthermore, the production of reactive oxygen species (ROS), malondialdehyde (MDA) level as well as glutathione (GSH) level was also decreased by treatment of ethanol extract of N.oceanica. The ethanol extract of N. oceanica also suppresses IκB degradation as well as p50 and p65 translocation into the nucleus in LPS-treated mice brain. Associated with the inhibitory effect on neuroinflammation and oxidative stress, ethanol extract of N. oceanica suppressed Aβ1-42 generation through down-regulation of APP and BACE1 expression in in vivo. These results suggest that ethanol extract of N. oceanica ameliorated memory impairment via anti-inflammatory, anti-oxidant and anti-amyloidogenic mechanisms.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results