1. Prognostic significance and the role in TNM stage of extranodal metastasis within regional lymph nodes station in gastric carcinoma
- Author
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Xiao-Long Chen, Zhi-Xin Chen, Yu-Hui Xu, Kun Yang, Xin-Zu Chen, Jiankun Hu, Bo Zhang, Kai Liu, Zong-Guang Zhou, Jia-Ping Chen, Lin-Yong Zhao, Lian Xue, and Wei-Han Zhang
- Subjects
extranodal metastasis ,Adult ,Male ,medicine.medical_specialty ,Prognostic factor ,Pathology ,medicine.medical_treatment ,C-index ,Kaplan-Meier Estimate ,Gastric carcinoma ,030230 surgery ,Gastroenterology ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,gastric carcinoma ,Neoplasm Metastasis ,Stage (cooking) ,Aged ,Neoplasm Staging ,TNM stage ,Tumor size ,business.industry ,West china ,Middle Aged ,Prognosis ,medicine.disease ,digestive system diseases ,Oncology ,030220 oncology & carcinogenesis ,Female ,Gastrectomy ,Lymph ,business ,Research Paper - Abstract
The role of extranodal metastasis (ENM) in TNM stage in gastric carcinoma (GC) is controversial. This study was aimed to make a detailed investigation of the prognostic significance and the role in TNM stage of ENM in GC. The patients with primary GC, who underwent gastrectomy with curative intention in West China Hospital from January 2005 to December 2011, were retrospectively enrolled. The prognosis and clinicopathological traits were compared between ENM positive (ENMP) and negative (ENMN) groups in all patients, TNM I-II, III and IV stages, respectively. The significance of the number and the role in TNM stage of ENM were also assessed. In our study, 1457 patients were enrolled, with 1324 (90.9%) in ENMN group and 133 (9.1%) in ENMP group. ENMP group had significantly more advanced GC and worse prognosis (all p2 subgroup had remarkably larger tumor size (p=0.002) and more advanced N stage (p=0.016) than ENM=1-2 subgroup. The number of ENM was an independent prognostic factor in ENMP group (p=0.029). The prognosis of ENM>2 in TNM I-III stages was significantly worse than ENMN patients in TNM III stage. The C-index of TNM stage plus the number of ENM was significantly higher than that of current TNM stage alone (p=0.005). In conclusion, the patients in ENMP subgroup had more advanced GC and worse prognosis than those in ENMN subgroup. It might be more reasonable to categorize ENM>2 into TNM IV stage.
- Published
- 2016