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Your search keyword '"Kishimoto, Mitsuo"' showing total 6 results
Start Over Author "Kishimoto, Mitsuo" Journal oncotarget
6 results on '"Kishimoto, Mitsuo"'

1. Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma

Author

Yamazato, Yuzo, primary, Shiozaki, Atsushi, additional, Ichikawa, Daisuke, additional, Kosuga, Toshiyuki, additional, Shoda, Katsutoshi, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Konishi, Eiichi, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2018
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2. Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma

Author

Shiozaki, Atsushi, primary, Hikami, Shoichiro, additional, Ichikawa, Daisuke, additional, Kosuga, Toshiyuki, additional, Shimizu, Hiroki, additional, Kudou, Michihiro, additional, Yamazato, Yuzo, additional, Kobayashi, Toshiyuki, additional, Shoda, Katsutoshi, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Konishi, Eiichi, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2018
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3. Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma

Author

Kobayashi, Toshiyuki, primary, Shiozaki, Atsushi, additional, Nako, Yoshito, additional, Ichikawa, Daisuke, additional, Kosuga, Toshiyuki, additional, Shoda, Katsutoshi, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Konishi, Eiichi, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2018
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4. Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma

Author

Shiozaki, Atsushi, primary, Kudou, Michihiro, additional, Ichikawa, Daisuke, additional, Shimizu, Hiroki, additional, Arita, Tomohiro, additional, Kosuga, Toshiyuki, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2017
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5. Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma

Author

Ariyoshi, Yosuke, primary, Shiozaki, Atsushi, additional, Ichikawa, Daisuke, additional, Shimizu, Hiroki, additional, Kosuga, Toshiyuki, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2016
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6. Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma.

Author

Ariyoshi Y, Shiozaki A, Ichikawa D, Shimizu H, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, and Otsuji E

Subjects
Adult, Aged, Aged, 80 and over, Apoptosis genetics, Biomarkers, Tumor genetics, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Cell Line, Tumor, Cell Proliferation genetics, Epithelial-Mesenchymal Transition genetics, Esophageal Neoplasms mortality, Esophageal Neoplasms pathology, Esophageal Squamous Cell Carcinoma, Female, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Signal Transduction genetics, Sodium-Hydrogen Exchanger 1 genetics, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell genetics, Esophageal Neoplasms diagnosis, Esophageal Neoplasms genetics, Genes, Tumor Suppressor, Sodium-Hydrogen Exchanger 1 physiology
Abstract

Na+/H+ exchanger 1 (NHE1) is a plasma membrane transporter that controls intracellular pH and regulates apoptosis and invasion in various cancer cells. However, the function of NHE1 in esophageal squamous cell carcinoma (ESCC) cells and the relationship between the expression of NHE1 and prognosis of ESCC remain unclear. We found that the knockdown of NHE1 in ESCC cells inhibited apoptosis and promoted cell proliferation, migration, and invasion and showed increases in Snail, β-catenin, and activation of PI3K-AKT signaling, which was consistent with the results obtained from microarrays. Microarrays results suggested that the knockdown of NHE1 suppressed Notch signaling pathway. An immunohistochemical investigation of 61 primary ESCC samples revealed that NHE1 was expressed at higher levels in well-differentiated tumors. The 5-year survival rate was poorer in the NHE1 low group (57.0%) than in the NHE1 high group (82.8%). Multivariate analyses revealed that the weak expression of NHE1 was associated with shorter postoperative survival (hazard ratio 3.570, 95% CI 1.291-11.484, p = 0.0135).We herein demonstrated that the suppression of NHE1 in ESCC may enhance malignant potential by mediating PI3K-AKT signaling and EMT via Notch signaling, and may be related to a poor prognosis in patients with ESCC.

Published
2017
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