Search

Your search keyword '"Presta, Marco"' showing total 9 results
Start Over Author "Presta, Marco" Journal oncotarget
9 results on '"Presta, Marco"'

3. U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis

Author

Caccuri, Francesca, primary, Ronca, Roberto, additional, Laimbacher, Andrea S., additional, Berenzi, Angiola, additional, Steimberg, Nathalie, additional, Campilongo, Federica, additional, Mazzuca, Pietro, additional, Giacomini, Arianna, additional, Mazzoleni, Giovanna, additional, Benetti, Anna, additional, Caselli, Elisabetta, additional, Presta, Marco, additional, Luca, Dario Di, additional, Fraefel, Cornel, additional, and Caruso, Arnaldo, additional

Published
2017
Full Text
View/download PDF

4. The importance of the genomic landscape in Waldenström's Macroglobulinemia for targeted therapeutical interventions

Author

Sacco, Antonio, primary, Fenotti, Adriano, additional, Affò, Loredana, additional, Bazzana, Stefano, additional, Russo, Domenico, additional, Presta, Marco, additional, Malagola, Michele, additional, Anastasia, Antonella, additional, Motta, Marina, additional, Patterson, Christopher J., additional, Rossi, Giuseppe, additional, Imberti, Luisa, additional, Treon, Steven P., additional, Ghobrial, Irene M., additional, and Roccaro, Aldo M., additional

Published
2017
Full Text
View/download PDF

9. The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors.

Author

Liekens S, Noppen S, Gijsbers S, Sienaert R, Ronca R, Tobia C, and Presta M

Subjects
Animals, Apoptosis drug effects, Blotting, Western, Cell Proliferation drug effects, Cidofovir, Cytosine pharmacology, Embryo, Nonmammalian cytology, Embryo, Nonmammalian metabolism, Endothelium, Vascular cytology, Endothelium, Vascular drug effects, Endothelium, Vascular metabolism, Female, Fibroblasts cytology, Fibroblasts drug effects, Fibroblasts metabolism, Humans, Immunoenzyme Techniques, Lung Neoplasms metabolism, Lung Neoplasms pathology, Melanoma, Experimental metabolism, Melanoma, Experimental pathology, Mice, Mice, SCID, Papillomavirus Infections drug therapy, Papillomavirus Infections pathology, Papillomavirus Infections virology, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, Zebrafish embryology, Antiviral Agents pharmacology, Cytosine analogs & derivatives, Embryo, Nonmammalian drug effects, Fibroblast Growth Factor 2 antagonists & inhibitors, Lung Neoplasms secondary, Melanoma, Experimental prevention & control, Organophosphonates pharmacology, Papillomaviridae drug effects
Abstract

The FDA-approved anti-DNA virus agent cidofovir (CDV) is being evaluated in phase II/III clinical trials for the treatment of human papillomavirus (HPV)-associated tumors. However, previous observations had shown that CDV also inhibits the growth of vascular tumors induced by fibroblast growth factor-2 (FGF2)-transformed FGF2-T-MAE cells. Here, we demonstrate that CDV inhibits metastasis induced by FGF2-driven, virus-independent tumor cells. Pre-treatment of luciferase-expressing FGF2-T-MAE cells with CDV reduced single cell survival and anchorage-independent growth in vitro and lung metastasis formation upon intravenous inoculation into SCID mice. This occurred in the absence of any effect on homing of FGF2-T-MAE cells to the lungs and on the growth of subconfluent cell cultures or subcutaneous tumors in mice. Accordingly, CDV protected against lung metastasis when given systemically after tumor cell injection. Lung metastases in CDV-treated mice showed reduced Ki67 expression and increased nuclear accumulation of p53, indicating that CDV inhibits metastasis by affecting single cell survival properties. The anti-metastatic potential of CDV was confirmed on B16-F10 melanoma cells, both in zebrafish embryos and mice. These findings suggest that CDV may have therapeutic potential as an anti-metastatic agent and warrants further study to select those tumor types that are most likely to benefit from CDV therapy.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results