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Your search keyword '"Yang, Lifang"' showing total 11 results
Start Over Author "Yang, Lifang" Journal oncotarget
11 results on '"Yang, Lifang"'

2. Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1/LSF-MMP2/CD44 axes

Author

Luo, Xiangjian, primary, Li, Namei, additional, Zhong, Juanfang, additional, Tan, Zheqiong, additional, Liu, Ying, additional, Dong, Xin, additional, Cheng, Can, additional, Xu, Zhijie, additional, Li, Hongde, additional, Yang, Lifang, additional, Tang, Min, additional, Weng, Xinxian, additional, Yi, Wei, additional, Liu, Jikai, additional, and Cao, Ya, additional

Published
2016
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3. Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis

Author

Luo, Xiangjian, primary, Yang, Lifang, additional, Xiao, Lanbo, additional, Xia, Xiaofeng, additional, Dong, Xin, additional, Zhong, Juanfang, additional, Liu, Ying, additional, Li, Namei, additional, Chen, Ling, additional, Li, Hongde, additional, Li, Wei, additional, Liu, Wenbin, additional, Yu, Xinfang, additional, Chen, Hanyong, additional, Tang, Min, additional, Weng, Xinxian, additional, Yi, Wei, additional, Bode, Ann, additional, Dong, Zigang, additional, Liu, Jikai, additional, and Cao, Ya, additional

Published
2015
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6. miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma

Author

Zhao, Luqing, primary, Tang, Min, additional, Hu, Zheyu, additional, Yan, Bin, additional, Pi, Weiwei, additional, Li, Zhi, additional, Zhang, Jing, additional, Zhang, Liqin, additional, Jiang, Wuzhong, additional, Li, Guo, additional, Qiu, Yuanzheng, additional, Hu, Fang, additional, Liu, Feng, additional, Lu, Jingchen, additional, Chen, Xue, additional, Xiao, Lanbo, additional, Xu, Zhijie, additional, Tao, Yongguang, additional, Yang, Lifang, additional, Bode, Ann M., additional, Dong, Zigang, additional, Zhou, Jian, additional, Fan, Jia, additional, Sun, Lunquan, additional, and Cao, Ya, additional

Published
2015
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7. EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

Author

Yang, Lifang, primary, Liu, Liyu, additional, Xu, Zhijie, additional, Liao, Weihua, additional, Feng, Deyun, additional, Dong, Xin, additional, Xu, San, additional, Xiao, Lanbo, additional, Lu, Jingchen, additional, Luo, Xiangjian, additional, Tang, Min, additional, Bode, Ann M., additional, Dong, Zigang, additional, Sun, Lunquan, additional, and Cao, Ya, additional

Published
2015
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8. Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production

Author

Yu, Xinfang, primary, Deng, Qipan, additional, Li, Wei, additional, Xiao, Lanbo, additional, Luo, Xiangjian, additional, Liu, Xiaolan, additional, Yang, Lifang, additional, Peng, Songling, additional, Ding, Zhihui, additional, Feng, Tao, additional, Zhou, Jian, additional, Fan, Jia, additional, Bode, Ann M., additional, Dong, Zigang, additional, Liu, Jikai, additional, and Cao, Ya, additional

Published
2014
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10. Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1 / LSF- MMP2 / CD44 axes.

Author

Luo X, Li N, Zhong J, Tan Z, Liu Y, Dong X, Cheng C, Xu Z, Li H, Yang L, Tang M, Weng X, Yi W, Liu J, and Cao Y

Subjects
Adenosine Triphosphate metabolism, Cell Adhesion drug effects, Cell Line, Tumor, DNA-Binding Proteins genetics, Gene Expression Regulation, Neoplastic drug effects, Humans, Hyaluronan Receptors genetics, Matrix Metalloproteinase 2 genetics, Neoplasms genetics, Neoplasms metabolism, Neoplasms pathology, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha genetics, Proto-Oncogene Proteins c-fos genetics, Reactive Oxygen Species metabolism, Signal Transduction drug effects, Signal Transduction genetics, Terpenes pharmacology, Transcription Factors genetics, Cell Movement drug effects, DNA-Binding Proteins metabolism, Hyaluronan Receptors metabolism, Matrix Metalloproteinase 2 metabolism, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha metabolism, Proto-Oncogene Proteins c-fos metabolism, Transcription Factors metabolism
Abstract

Grifolin, a farnesyl phenolic compound isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens, exhibits effective antitumor bioactivity in previous study of our group and other lab. In this study, we observed that grifolin inhibited tumor cells adhesion and migration. Moreover, grifolin reduced reactive oxygen species (ROS) production and caused cellular ATP depletion in high-metastatic tumor cells. PGC1α (Peroxisome proliferator-activated receptor γ, coactivator 1α) encodes a transcriptional co-activator involved in mitochondrial biogenesis and respiration and play a critical role in the maintenance of energy homeostasis. Interestingly, grifolin suppressed the mRNA as well as protein level of PGC1α. We further identified that MMP2 and CD44 expressions were PGC1α inducible. PGC1α can bind with metastatic-associated transcription factors: Fra-1 and LSF and the protein-protein interaction was attenuated by grifolin treatment. Overall, these findings suggest that grifolin decreased ROS generation and intracellular ATP to suppress tumor cell adhesion/migration via impeding the interplay between PGC1α and Fra-1 /LSF-MMP2/CD44 axes. Grifolin may develop as a promising lead compound for antitumor therapies by targeting energy metabolism regulator PGC1α signaling.

Published
2016
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11. Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production.

Author

Yu X, Deng Q, Li W, Xiao L, Luo X, Liu X, Yang L, Peng S, Ding Z, Feng T, Zhou J, Fan J, Bode AM, Dong Z, Liu J, and Cao Y

Subjects
Antineoplastic Agents pharmacology, Baculoviral IAP Repeat-Containing 3 Protein, Basidiomycota chemistry, Blotting, Western, Cell Line, Tumor, Gene Expression drug effects, Humans, Inhibitor of Apoptosis Proteins metabolism, NF-kappa B metabolism, Necrosis chemically induced, RNA Interference, Receptor-Interacting Protein Serine-Threonine Kinases genetics, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction drug effects, Tumor Necrosis Factor-alpha genetics, Ubiquitin-Protein Ligases metabolism, Ubiquitination drug effects, Reactive Oxygen Species metabolism, Receptor-Interacting Protein Serine-Threonine Kinases metabolism, Sesquiterpenes pharmacology, Tumor Necrosis Factor-alpha metabolism
Abstract

Necroptosis/regulated necrosis is a caspase-independent, but receptor interacting protein kinase (RIPK)-dependent form of cell death. In previous studies, neoalbaconol (NA), a constituent extracted from Albatrellus confluens, was demonstrated to induce necroptosis in some cancer cell lines. The molecular mechanism of NA-induced necroptosis is described in this research study. We determined that NA-induced cell death is partly dependent on tumor necrosis factor α (TNFα) feed-forward signaling. More importantly, NA abolished the ubiquitination of RIPK1 by down-regulating E3 ubiquitin ligases, cellular inhibitors of apoptosis protein 1/2 (cIAP1/2) and TNFα receptor-associated factors (TRAFs). The suppression of RIPK1 ubiquitination induced the activation of the non-canonical nuclear factor-κB (NF-κB) pathway and stimulated the transcription of TNFα. Moreover, we also found that NA caused RIPK3-mediated reactive oxygen species (ROS) production and contribution to cell death. Taken together, these results suggested that two distinct mechanisms are involved in NA-induced necroptosis and include RIPK1/NF-κB-dependent expression of TNFα and RIPK3-dependent generation of ROS.

Published
2015
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