Search

Your search keyword '"Zhou, Yuxin"' showing total 9 results
Start Over Author "Zhou, Yuxin" Journal oncotarget
9 results on '"Zhou, Yuxin"'

6. GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway

Author

Zhao, Yue, primary, Sun, Yang, additional, Ding, Youxiang, additional, Wang, Xiaoping, additional, Zhou, Yuxin, additional, Li, Wenjun, additional, Huang, Shaoliang, additional, Li, Zhiyu, additional, Kong, Lingyi, additional, Guo, Qinglong, additional, and Lu, Na, additional

Published
2015
Full Text
View/download PDF

9. Baicalein reduces angiogenesis in the inflammatory microenvironment via inhibiting the expression of AP-1.

Author

Huang Y, Miao Z, Hu Y, Yuan Y, Zhou Y, Wei L, Zhao K, Guo Q, and Lu N

Subjects
Active Transport, Cell Nucleus, Animals, Cell Line, Cell Movement drug effects, Cell Proliferation drug effects, Cell Survival drug effects, Chick Embryo, Flavanones chemistry, Human Umbilical Vein Endothelial Cells drug effects, Human Umbilical Vein Endothelial Cells metabolism, Humans, Mice, Neovascularization, Pathologic metabolism, Protein Binding, Rats, Signal Transduction drug effects, Transcription Factor AP-1 chemistry, Transcription Factor AP-1 metabolism, Flavanones pharmacology, Gene Expression Regulation, Neoplastic drug effects, Neovascularization, Pathologic genetics, Transcription Factor AP-1 genetics, Tumor Microenvironment drug effects, Tumor Microenvironment genetics
Abstract

Increasing clinical and experimental studies have demonstrated that refractory chronic inflammation will result in malignant tumor and anti-angiogenic therapy may be an effective way to thwart the progression. Baicalein, one of the major active flavanoids found in Scutellaria baicalensis Georgi, has been exhibited potent anti-inflammation and anti-tumor effects by reducing angiogenesis. However, the exact mechanism of baicalein on endothelial cells in inflammatory microenvironment was not clear yet. Here, we investigated the anti-angiogenic effect of baicalein by incubating human umbilical vein endothelial cells (HUVECs) with THP-1 conditioned medium in vitro. The tube formation of HUVECs and microvessel outgrowth of rat aorta were attenuated, as well as the number of newly formed blood vessels in chicken chorioallantoic membrane (CAM) was reduced by baicalein. This anti-angiogenic effect was mainly on account of the inhibited motility, migration and invasion of HUVECs. In addition, mechanistic studies showed that baicalein could bind to AP-1 directly and the expression of c-Jun and c-Fos in HUVECs was reduced, accompanied by their increased proteasomal degradation. Besides, baicalein suppressed the nuclear translation, heterodimer formation and DNA binding affinity of c-Jun and c-Fos. What's more, the anti-angiogenic effect of baicalein was further confirmed by matrigel plug assay in vivo. Taken together, our study demonstrated that baicalein could exert its anti-angiogenic effect in the inflammation microenvironment via inhibiting the transcriptional activity of AP-1, which suggested that baicalein might be an alternative treatment against refractory chronic inflammation.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results