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3. The negative prognostic impact of derivative 9 deletions in patients who received hydroxyurea treatment for chronic myelogenous leukemia in the chronic phase

Author

Hai-Rong Qiu, Wei Xu, Jianyong Li, Si-Xuan Qian, Wei Wu, Run Zhang, Su-Jiang Zhang, and Yu Zhu

Subjects
Adult, Male, Cancer Research, Adolescent, Chromosomal translocation, Risk Assessment, Sensitivity and Specificity, Fusion gene, Young Adult, Risk Factors, hemic and lymphatic diseases, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, medicine, Humans, Hydroxyurea, In patient, Genetic Predisposition to Disease, Genetic Testing, neoplasms, Aged, Genetics, ABL, medicine.diagnostic_test, business.industry, breakpoint cluster region, Myeloid leukemia, Reproducibility of Results, Hematology, Middle Aged, medicine.disease, Prognosis, Treatment Outcome, Oncology, Cancer research, Female, business, Chromosomes, Human, Pair 9, Gene Deletion, Fluorescence in situ hybridization, Chronic myelogenous leukemia
Abstract

Chronic myeloid leukemia (CML) is characterized by the formation of the BCR/ABL fusion gene, as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22. This study was to investigate the incidence and prognostic significance of derivative chromosome 9 (der(9)) deletions in CML patients who received hydroxyurea treatment in the chronic phase.Fluorescence in situ hybridization (FISH) analysis was used to assess the der(9) deletion status of 48 CML patients in blast crisis (CMLBC).Among the 48 CML patients, 8 (16.7%) showed der(9) deletions, and the deletions were also existent at diagnosis. The median duration of the chronic phase for patients with der(9) deletions was 18 (range 4-38) months compared to 48 (range 0-204) months for patients without deletions (p0.001). Der(9) deletions were not associated with increased karyotypic instability. There was no difference in the probability of the der(9) deletions between the cases having progressed to myeloid or lymphoid blast crisis.The results indicated that the FISH technique could effectively detect der(9) deletions. CML patients with der(9) deletions show more rapid progression and poorer prognosis, and the deletion status is a powerful prognostic factor.

Published
2009

4. Erste DGHO-Frühjahrstagung in Berlin: Brückenschlag zwischen Versorgung, Wissenschaft und Politik

Author

Fernanda Maris Peria, Marcus Gorschlüter, Tal Grenader, Su-Jiang Zhang, Carlos Gilberto Carlotti Júnior, Olav Gressner, Alexey Surov, Jochen W.U. Fries, Wei Xu, John Strehl, Ingo G.H. Schmidt-Wolf, Dirk L. Stippel, Constantin Reinus, Michael Buerke, Benedicto Oscar Colli, Ulrich Mey, Lei Fan, José Paulo Montemor, Martin R. Weihrauch, Siegfried Seeber, Burkhard Deuss, Curd Behrmann, Wolf-Karsten Hofmann, Endris John, Ulrich Hacker, Karin Berger, Lauren C. Harshman, Jian-Yong Li, Rolf-Peter Spielmann, C Plesnila-Frank, Manfred Braun, Ruth Isacson, Dirk Arnold, Jan Janssen, Sandy Srinivas, Hueseyin-Taylan Oeney, Karin Jordan, Henning Popp, Nicolaus Friedrichs, Carlos Roberto Monti, Stephan Schmitz, Holger Deertz, Orit Barenholz, Tilman Sauerbruch, Ora Rosengarten, Wolfgang Schramm, Li-Juan Chen, René-Olivier Mirimanoff, Uzi Beller, Hans-Jochen Illiger, Carl Richard Meier, Hui-Fen Zhou, Jordana Hyman, Alberto Gabizon, Tanja Vollmer, Henning Bovenschulte, Jochen Casper, Axel Meeßen, Thomas Küchler, Norbert Gattermann, Denis Castaing, Si-Xuan Qian, Luis Salvador Petrilli, Christoph Kahl, Hai-Rong Qiu, Inken Hilgendorf, Eric Vibert, Ulrich Wedding, Anton Tsamaloukas, Susanne Rotermund, Mathias Freund, Martin Steder, and Oliver Coutelle

Subjects
Cancer Research, Oncology, Hematology, General Medicine
Published
2008

5. Trisomy 22 as the Sole Abnormality is an Important Marker for the Diagnosis of Acute Myeloid Leukemia with Inversion 16

Author

Wei Xu, Hui-Fen Zhou, Li-Juan Chen, Hai-Rong Qiu, Lei Fan, Jianyong Li, Si-Xuan Qian, and Su-Jiang Zhang

Subjects
Adult, Genetic Markers, Male, congenital, hereditary, and neonatal diseases and abnormalities, Cancer Research, Myeloid, Adolescent, Trisomy, Trisomy 22, Young Adult, Chromosome 16, hemic and lymphatic diseases, medicine, Humans, Genetic Predisposition to Disease, Aged, Chromosomal inversion, Genetics, business.industry, Myeloid leukemia, Hematology, General Medicine, Middle Aged, biochemical phenomena, metabolism, and nutrition, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Oncology, Genetic marker, Chromosome Inversion, Cancer research, Female, business, Chromosomes, Human, Pair 16
Abstract

The inversion of chromosome 16 (inv(16) (p13q22)) and the related t(16;16)(p13;q22) are chromosomal aberrations observed in approximately 10% of de novo acute myeloid leukemia (AML), mostly classified as M4Eo subtype, and associated with a relatively favorable outcome. However, it is a cryptic rearrangement and often difficult to recognize in conventional cytogenetics (CC). Trisomy 22 is an uncommon karyotypic aberration in AML and is often associated with inv(16)(p13q22). The aim of this study was to explore the value of trisomy 22 in the diagnosis of AML with inv(16).Dual-color interphase fluorescence in situ hybridization (FISH) was performed in 19 AML cases with trisomy 22 abnormality shown by R-banding CC. The probe was a two-color break-apart probe for CBFbeta on the centromeric side and the telomeric side.R-banding CC did not reveal inv(16) in any of the 19 AML with trisomy 22, but FISH analysis showed inv(16) in 11 cases and del(16)(q22) in 1 case. Among the 11 cases with inv(16), 9 showed trisomy 22 as the sole abnormality, 1 was complicated by trisomy 8, and 1 was del(16)(q22).This study further confirmed that trisomy 22 as the sole abnormality can be regarded as an important marker for inv(16) in AML.

Published
2008

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