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Aim: To evaluate the association between vital signs collected at the patient's entrance to the emergency department and the risk levels of the Manchester Triage System (MTS). Method: This is a retrospective observational study; whose sample was 154,714 patients. The exposure factor was the vital signs data, and the primary endpoint was the level of risk of MTS. Statistical, descriptive and inferential analyzes were conducted. Results: The most evaluated vital data was pain intensity; blood pressure was the least evaluated. Changes in heart rate to more or less of physiological patterns have increased the clinical priority of patients. Discussion: The higher the level of severity of MTS, the greater the variability of the mean of the vital signs evaluated. Conclusion: More severe patients tend to present greater variation in terms of vital signs on admission to the emergency department. [ABSTRACT FROM AUTHOR]