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Your search keyword '"Pellegrini, Marco"' showing total 14 results
Start Over Author "Pellegrini, Marco" Journal ophthalmology
14 results on '"Pellegrini, Marco"'

3. Reply

Author

Fung, Adrian T., primary, Waldstein, Sebastian M., additional, Gal-Or, Orly, additional, Pellegrini, Marco, additional, Freund, K. Bailey, additional, and Shields, Carol L., additional

Published
2021
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4. Focal Scleral Nodule

Author

Fung, Adrian T., primary, Waldstein, Sebastian M., additional, Gal-Or, Orly, additional, Pellegrini, Marco, additional, Preziosa, Chiara, additional, Shields, Jerry A., additional, Welch, R. Joel, additional, Dolz-Marco, Rosa, additional, Sarraf, David, additional, Nagiel, Aaron, additional, Lalane, Robert, additional, Jung, Jesse J., additional, Ghazi, Nicola G., additional, Ramtohul, Prithvi, additional, Arnold, Jennifer J., additional, Sakurada, Yoichi, additional, Choudhry, Netan, additional, Balaratnasingam, Chandrakumar, additional, Freund, K. Bailey, additional, and Shields, Carol L., additional

Published
2020
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5. Reply

Author

Dolz-Marco, Rosa, primary, Glover, Jay P., additional, Gal-Or, Orly, additional, Litts, Katie M., additional, Messinger, Jeffrey D., additional, Zhang, Yuhua, additional, Cozzi, Mariano, additional, Pellegrini, Marco, additional, Freund, K. Bailey, additional, Staurenghi, Giovanni, additional, and Curcio, Christine A., additional

Published
2019
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6. Choroidal and Sub-Retinal Pigment Epithelium Caverns: Multimodal Imaging and Correspondence with Friedman Lipid Globules

Author

Dolz-Marco, Rosa, Glover, Jay P., Gal-Or, Orly, Litts, Katie M., Messinger, Jeffrey D., Zhang, Yuhua, Cozzi, Mariano, Pellegrini, Marco, Freund, K. Bailey, Staurenghi, Giovanni, and Curcio, Christine A.

Subjects
Aged, 80 and over, Male, genetic structures, Choroid, Fundus Oculi, Visual Acuity, Retinal Pigment Epithelium, Lipids, Multimodal Imaging, eye diseases, Article, Macular Degeneration, Cross-Sectional Studies, Geographic Atrophy, Humans, Female, sense organs, Fluorescein Angiography, Tomography, Optical Coherence, Aged, Follow-Up Studies, Retrospective Studies
Abstract

To survey Friedman lipid globules by high-resolution histologic examination and to compare with multimodal imaging of hyporeflective caverns in eyes with geographic atrophy (GA) secondary to age-related macular (AMD) and other retinal diseases.Histologic survey of donor eyes with and without AMD. Clinical case series with multimodal imaging analysis.Donor eyes (n = 139; 26 with early AMD, 13 with GA, 40 with nAMD, 52 with a healthy macula, and 8 with other or unknown characteristics) and 41 eyes of 28 participants with GA (n = 16), nAMD (n = 8), Stargardt disease (n = 4), cone dystrophy (n = 2), pachychoroid spectrum (n = 6), choroidal hemangioma (n = 1), and healthy eyes (n = 4).Donor eyes were prepared for macula-wide epoxy resin sections through the foveal and perifoveal area. In patients, caverns were identified as nonreflective spaces on OCT images. Multimodal imaging included color and red-free fundus photography; fundus autofluorescence; fluorescein and, indocyanine green angiography; OCT angiography; near-infrared reflectance; and confocal multispectral (MultiColor [Spectralis, Heidelberg Engineering, Germany]) imaging.Presence and morphologic features of globules, and presence and appearance of caverns on multimodal imaging.Globules were found primarily in the inner choroidal stroma (91.0%), but also localized to the sclera (4.9%) and neovascular membranes (2.1%). Mean diameters of solitary and multilobular globules were 58.9±37.8 μm and 65.4±27.9 μm, respectively. Globules showed morphologic signs of dynamism including pitting, dispersion, disintegration, and crystal formation. Evidence for inflammation in the surrounding tissue was absent. En face OCT rendered sharply delimited hyporeflective areas as large as choroidal vessels, frequently grouped around choroid vessels or in the neovascular tissue. Cross-sectional OCT revealed a characteristic posterior hypertransmission. OCT angiography showed absence of flow signal within caverns.Based on prior literature documenting OCT signatures of tissue lipid in atheroma and nAMD, we speculate that caverns are lipid rich. Globules, with similar sizes and tissue locations in AMD and healthy persons, are candidates for histologic correlates of caverns. The role of globules in chorioretinal physiologic features, perhaps as a lipid depot for photoreceptor metabolism, is approachable through clinical imaging.

Published
2017

7. Choroidal and Sub-Retinal Pigment Epithelium Caverns

Author

Dolz-Marco, Rosa, primary, Glover, Jay P., additional, Gal-Or, Orly, additional, Litts, Katie M., additional, Messinger, Jeffrey D., additional, Zhang, Yuhua, additional, Cozzi, Mariano, additional, Pellegrini, Marco, additional, Freund, K. Bailey, additional, Staurenghi, Giovanni, additional, and Curcio, Christine A., additional

Published
2018
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10. Primary Transpupillary Thermotherapy for Choroidal Melanoma in 391 Cases

Author

Mashayekhi, Arman, primary, Shields, Carol L., additional, Rishi, Pukhraj, additional, Atalay, Hatice T., additional, Pellegrini, Marco, additional, McLaughlin, John P., additional, Patrick, Kaitlin A., additional, Morton, Spenser J., additional, Remmer, Meredith H., additional, Parendo, Anthony, additional, Schlitt, Meghan A., additional, and Shields, Jerry A., additional

Published
2015
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14. Focal Scleral Nodule: A New Name for Solitary Idiopathic Choroiditis and Unifocal Helioid Choroiditis.

Author

Fung, Adrian T., Waldstein, Sebastian M., Gal-Or, Orly, Pellegrini, Marco, Preziosa, Chiara, Shields, Jerry A., Welch, R. Joel, Dolz-Marco, Rosa, Sarraf, David, Nagiel, Aaron, Lalane, Robert, Jung, Jesse J., Ghazi, Nicola G., Ramtohul, Prithvi, Arnold, Jennifer J., Sakurada, Yoichi, Choudhry, Netan, Balaratnasingam, Chandrakumar, Freund, K. Bailey, and Shields, Carol L.

Subjects
*POLYPOIDAL choroidal vasculopathy, *OPTIC disc, *RHODOPSIN, *COLOR photography, *INDOCYANINE green, *SCLERA
Abstract

To evaluate multimodal imaging findings of solitary idiopathic choroiditis (SIC; also known as unifocal helioid choroiditis) to clarify its origin, anatomic location, and natural course. Multicenter retrospective observational case series. Sixty-three patients with SIC in 1 eye. Demographic and clinical data were collected. Multimodal imaging included color fundus photography, OCT (including swept-source OCT), OCT angiography (OCTA), fundus autofluorescence, fluorescein and indocyanine green angiography, and B-scan ultrasonography. Standardized grading of imaging features. Mean age at presentation was 56 ± 15 years (range, 12–83 years). Mean follow-up duration in 39 patients was 39 ± 55 months (range, 1 month–25 years). The lesions measured a mean of 2.4 × 2.1 mm in basal diameter, were located inferior (64%) or nasal to the optic disc, and appeared yellow (53%). No systemic associations were found. The lesions all appeared as an elevated subretinal mass, with OCT demonstrating all lesions to be confined to the sclera, not the choroid. On OCT, the deep lesion margin was visible in 12 eyes with a mean lesion thickness of 0.6 mm. Overlying choroidal thinning or absence was seen in 95% (mean choroidal thickness, 28 ± 35 μm). Mild subretinal fluid was observed overlying the lesions in 9 patients (14%). Retinal pigment epithelial disruption and overlying retinal thinning was observed in 56% and 57%, respectively. OCT angiography was performed in 13 eyes and demonstrated associated choroidal and lesional flow voids. Four lesions (6%) were identified at the macula, leading to visual loss in 1 patient. One lesion demonstrated growth and another lesion showed spontaneous resolution. In this largest series to date, multimodal imaging of SIC demonstrated a scleral location in all patients. The yellow and white clinical appearance may be related to scleral unmasking resulting from atrophy of overlying tissues. Additional associated features included documentation of deep margin on swept-source OCT, trace subretinal fluid in a few patients, and OCTA evidence of lesional flow voids. Because of the scleral location of this lesion in every patient, a new name, focal scleral nodule, is proposed. [ABSTRACT FROM AUTHOR]

Published
2020
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