Search

Your search keyword '"Scott, William"' showing total 22 results
Start Over Author "Scott, William" Journal ophthalmology
22 results on '"Scott, William"'

1. Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes

Author

Aboobakar, Inas F., primary, Kinzy, Tyler G., additional, Zhao, Yan, additional, Fan, Baojian, additional, Pasquale, Louis R., additional, Qassim, Ayub, additional, Kolovos, Antonia, additional, Schmidt, Joshua M., additional, Craig, Jamie E., additional, Cooke Bailey, Jessica N., additional, Wiggs, Janey L., additional, Allingham, R. Rand, additional, Brilliant, Murray, additional, Budenz, Donald L., additional, Fingert, John H., additional, Gaasterland, Douglas, additional, Gaasterland, Teresa, additional, Haines, Jonathan L., additional, Hauser, Michael A., additional, Lee, Richard K., additional, Lichter, Paul R., additional, Liu, Yutao, additional, Moroi, Syoko, additional, Myers, Jonathan, additional, Pericak-Vance, Margaret, additional, Realini, Anthony, additional, Rhee, Doug, additional, Richards, Julia E., additional, Ritch, Robert, additional, Schuman, Joel S., additional, Scott, William K., additional, Singh, Kuldev, additional, Sit, Arthur J., additional, Vollrath, Douglas, additional, Weinreb, Robert N., additional, Wollstein, Gadi, additional, and Zack, Donald J., additional

Published
2023
Full Text
View/download PDF

3. Heritability of Choroidal Thickness in the Amish

Author

Sardell, Rebecca J., primary, Nittala, Muneeswar G., additional, Adams, Larry D., additional, Laux, Reneé A., additional, Cooke Bailey, Jessica N., additional, Fuzzell, Denise, additional, Fuzzell, Sarada, additional, Reinhart-Mercer, Lori, additional, Caywood, Laura J., additional, Horst, Violet, additional, Mackay, Tine, additional, Dana, Debbie, additional, Sadda, SriniVas R., additional, Scott, William K., additional, Stambolian, Dwight, additional, Haines, Jonathan L., additional, and Pericak-Vance, Margaret A., additional

Published
2016
Full Text
View/download PDF

6. Independent Effects of Complement Factor H Y402H Polymorphism and Cigarette Smoking on Risk of Age-Related Macular Degeneration

Author

Scott, William K., primary, Schmidt, Silke, additional, Hauser, Michael A., additional, Gallins, Paul, additional, Schnetz-Boutaud, Nathalie, additional, Spencer, Kylee L., additional, Gilbert, John R., additional, Agarwal, Anita, additional, Postel, Eric A., additional, Haines, Jonathan L., additional, and Pericak-Vance, Margaret A., additional

Published
2007
Full Text
View/download PDF

10. Reply

Author

Repka, Michael X., primary, Connett, John E., additional, and Scott, William E., additional

Published
1997
Full Text
View/download PDF

11. Authors' reply

Author

Repka, Michael X., primary, Connett, John E., additional, and Scott, William E., additional

Published
1996
Full Text
View/download PDF

22. Complement Factor H Increases Risk for Atrophic Age-Related Macular Degeneration

Author

Postel, Eric A., Agarwal, Anita, Caldwell, Jennifer, Gallins, Paul, Toth, Cynthia, Schmidt, Silke, Scott, William K., Hauser, Michael A., Haines, Jonathan L., and Pericak-Vance, Margaret A.

Subjects
*RETINAL degeneration, *PATHOLOGY, *GENETIC polymorphisms, *DISEASES
Abstract

Objective: To determine if the complement factor H gene (CFH) determines risk for development of geographic atrophy (GA). Design: Retrospective case–control study. Participants and Controls: The independent case–control data set contained 647 age-related macular degeneration (AMD) cases (grades 3, 4, or 5) and 163 controls (grades 1 or 2). Methods: To determine if CFH had any effect on determining risk for development of GA in an independent case–control data set of 647 AMD cases and 163 controls, the rs1061170 single-nucleotide polymorphism was tested for association, separating grades and analyzing them independently against the controls. Odds ratios were calculated using standard logistic regression models. Main Outcome Measures: The outcome variable was AMD affection status, and genotypes were coded according to a log-additive model. Results: There were 407 grade 5, 107 grade 4, 133 grade 3, 35 grade 2, and 128 grade 1 individuals. There was significant association with AMD when comparing grades 3, 4, and 5 versus the controls. The highest odds ratio was obtained when analyzing the grade-4 cases versus the grade-1 controls (OR = 3.217, P<0.0001). Conclusions: Our results indicate that CFH increases the risk of developing GA (grade 4) as well as neovascular (grade 5) and milder (grade 3) disease. Although neovascular disease is responsible for the majority of severe vision loss with AMD, GA is also a significant cause of vision loss, and without effective treatment. Therefore, an attempt to clarify its pathogenesis is of the utmost importance. [Copyright &y& Elsevier]

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results