1. Functional genetic variants of TGF-β1 and risk of tobacco-related oral carcinoma in high-risk Asian Indians
- Author
-
Gaur, Poonam, Mittal, Manasi, Mohanti, Bidhu Kalyan, and Das, Satya Narayan
- Subjects
- *
ORAL cancer risk factors , *PHYSIOLOGICAL effects of tobacco , *TRANSFORMING growth factors-beta , *CARCINOGENESIS , *GENETIC polymorphisms , *DISEASES , *INDIANS (Asians) - Abstract
Summary: Transforming growth factor (TGF)-β1, the most abundant isoform of TGF-β have been implicated in various stages of carcinogenesis such as epithelial to mesenchymal transition, enhanced expression of metalloproteases, down-regulation of cellular adhesion molecule, increased tumor motility and angiogenesis as well as local and systemic immunosuppression leading to a more aggressive and metastatic behavior. We assessed the association of TGF-β1 functional genetic polymorphisms at codon 10 (869 T>C) and 25 (915 G>C) of exon 1 in 140 patients with tobacco-related oral squamous cell carcinoma (OSCC) and 120 normal subjects by PCR–RFLP. The frequency of 869 CC genotype and C allele were significantly higher in patients as compared to controls (Pc , 0.024 and 0.0004, respectively) while no significant difference was observed in the frequency of 915 CC genotype and C allele. In logistic regression analysis CC genotype (OR, 3.87; 95% CI, 1.78–8.41) and C allele (OR, 2.20; 95% CI 1.51–3.20) appeared as susceptible while TT genotype and T allele as protective. In addition C869–C915 haplotype with OR of 2.48 at 95% CI, 1.51–4.06 significantly (P =0.0003) increased the risk of tobacco-related OSCC in Asian Indians. [Copyright &y& Elsevier]
- Published
- 2011
- Full Text
- View/download PDF