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3 results on '"Melville JC"'

1. Case report: golimumab-related osteonecrosis of the jaw.

Author

Ghosh YA, Pullara J, Rattan R, and Melville JC

Subjects
Humans, Diphosphonates adverse effects, Antibodies, Monoclonal adverse effects, Jaw pathology, Jaw Diseases chemically induced, Osteonecrosis chemically induced, Osteonecrosis diagnostic imaging, Bone Density Conservation Agents adverse effects, Bisphosphonate-Associated Osteonecrosis of the Jaw etiology
Abstract

Medication-related osteonecrosis of the jaw is an uncommon but highly morbid adverse event of certain medical therapies. Although classically induced by bisphosphonates, the recent advent of monoclonal antibodies is contributing to a rise in cases. In this case report, we present a rare case of golimumab-associated medication-related osteonecrosis of the jaw and discuss the possible mechanisms of pathogenesis., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Published
2023
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2. Expansile, mandibular lesion in a pediatric patient.

Author

Mañón VA, Vigneswaran N, Melville JC, Shum J, Wang XI, and Hanna I

Subjects
Humans, Child, Mandible pathology, Mandibular Neoplasms diagnostic imaging, Mandibular Neoplasms surgery, Mandibular Neoplasms pathology, Mandibular Diseases diagnostic imaging, Mandibular Diseases surgery, Mandibular Diseases pathology
Abstract

Competing Interests: Declarations of interest None.

Published
2023
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3. A technique for the treatment of oral-antral fistulas resulting from medication-related osteonecrosis of the maxilla: the combined buccal fat pad flap and radical sinusotomy.

Author

Melville JC, Tursun R, Shum JW, Young S, Hanna IA, and Marx RE

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Treatment Outcome, Adipose Tissue transplantation, Bisphosphonate-Associated Osteonecrosis of the Jaw complications, Bisphosphonate-Associated Osteonecrosis of the Jaw surgery, Maxillary Diseases etiology, Maxillary Diseases surgery, Oral Fistula etiology, Oral Fistula surgery, Sinusitis etiology, Sinusitis surgery, Surgical Flaps
Abstract

Objective: Bisphosphonates and monoclonal antibodies directed at osteoclastic function are frequently used to treat postmenopausal and corticosteroid-induced osteoporosis. They are also used in the treatment of certain metastatic malignancies. However, osteonecrosis of the jaw has been reported after intravenous, subcutaneous, or oral use of these agents. More than 12 million Americans and another 20 million worldwide are thought to be taking a bisphosphonate. Exposed bone with oral-antral fistulas has been known to occur increasingly as a specific presentation of what is now termed medication-related osteonecrosis of the jaws (MRONJ) with a specific International Classification of Diseases, 10th revision (ICD-10) code. Oral-antral communications caused by bisphosphonate concomitant with secondary sinusitis represent a unique treatment challenge for the oral and maxillofacial surgeon. The purpose of this article is to demonstrate a simple but effective technique to treat oral-antral communications caused by MRONJ., Study Design: With the review and approval of the University of Miami Internal Review Board, we identified 23 patients who had undergone this surgical procedure., Results: We report a 100% resolution of osteonecrosis of the jaw (ONJ) and sinusitis with repneumatization., Conclusions: The buccal fat pad and radical sinustomy can be used as an effective and predictable technique for the resolution of oral-antral fistulas caused by MRONJ., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2016
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