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[Display omitted] • Constructed a geochemical big data platform on the Tibetan Plateau. • Using GIS analysis, a filling map of geochemical elements was carried out. • The HF and Nd isotopic packing characteristics were explored. • Multivariate statistics were applied to explore mineralization characteristics. Tibet has received much attention as a pivotal area to explore the genesis of ore deposits. So far, a large number of researchers have conducted a lot of discussions on the geological conditions, genesis, distribution and scale of ore deposits in Tibet, and accumulated a plenty of isotopic test data. Isotopic data can reveal the geological changes of an area and analyze the metallogenic regularity. In this paper, combined with GIS (Geographic Information System) spatiotemporal analysis technology, Hf and Nd isotopic data mapping analysis has been carried out in Tibet. The mapping shows high zircons ε Hf (t) value and high whole rock ε Nd (t) value and low T DM c value on both sides of the Eastern Yarlung Zangbo Suture Zone and the Western Bangong-Nujiang Suture Zone. It indicates that the terranes in these two areas are relatively young and have typical characteristics of Cu and Au mineralization, which are favorable areas for the prospecting of Cu and Au. Combined with the geological fault characteristics of Tibet Plateau, the influence of terrane boundary on the deposit and the relevant characteristics of geochemical elements, three favorable targets for Cu and Au prospecting in Tibet Plateau are delineated by GIS analysis. The results show that the characteristics of isotopic data in Tibet Plateau are quite different in disparate terranes, and the isotopic analysis can quickly delineate the strategic prospecting targets. Therefore, using GIS technology for isotope analysis and metallogenic prediction provides important guiding significance for scientific prospecting. [ABSTRACT FROM AUTHOR]