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• An efficient geochemical evidence layer was generated. • The layer was used as a response to ore deposition processes. • The layer was applied for mineral exploration targeting. Recognition of mineralization-related geochemical footprints and modeling their multi-element dispersion patterns are important aspects to consider when "vectoring" toward undiscovered ore deposits. The collection, analysis, and interpretation of stream sediment geochemical data together make an exploration method that has proven to be successful at the district scale mineral exploration targeting. Identifying the possible sources of stream sediment geochemical anomalies and mapping evidence (i.e., footprints) of the underlying ore-forming processes, however, are not trivial tasks. This is because stream sediment samples represent transported material reflecting the entire geology upstream from the sample locations. Furthermore, indicator element distribution patterns are commonly strongly affected by local factors such as regolith, topographic gradient, vegetation density, and/or climate. Therefore, there is a need for finding a better geochemical anomaly separation method regarding the nature of geochemical data obtained from the area sampled. The main objectives of this study were (1) evaluating and comparing the spatial U-statistic and concentration–area fractal modeling methods of anomaly identification, both amenable to spatial analysis, for recognizing geochemical footprints of porphyry copper mineralization, and (2) measuring their performance in the context of district-scale exploration targeting in an area located in southeast Iran. Subsequently, the methods were first evaluated on a dataset of element contents to decompose anomalous populations. Finally, the geochemical model that proved more efficient with respect to predicting the known mineral deposits was integrated with additional evidence maps to delineate exploration targets. Our evaluation of the resulting geochemical targeting model demonstrated that the targets derived from this method are robust and worthy of follow-up exploration. [ABSTRACT FROM AUTHOR]