25 results on '"Spring, David R."'
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2. Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy.
3. Chemical probes targeting the kinase CK2: a journey outside the catalytic box
4. Efficient and selective antibody modification with functionalised divinyltriazines
5. General dual functionalisation of biomacromolecules via a cysteine bridging strategy
6. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction
7. Stereocontrolled semi-syntheses of deguelin and tephrosin† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra. See DOI: 10.1039/c6ob02659a Click here for additional data file
8. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
9. Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol
10. Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking
11. Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1–42)
12. A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds
13. Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity
14. Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa
15. Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics
16. A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds
17. Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening
18. Fluoride-free cross coupling using vinyldisiloxanes
19. Gemmacin B: bringing diversity back into focus
20. Diversity-oriented synthesis; a spectrum of approaches and results
21. Using chemical probes to investigate the sub-inhibitory effects of azithromycin
22. Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation
23. Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesisElectronic supplementary information (ESI) available: experimental techniques, apparatus, characterisation and spectroscopic data. See http://www.rsc.org/suppdata/ob/b4/b406488g/
24. Diversity-oriented synthesis; a challenge for synthetic chemistsElectronic supplementary information (ESI) available: Excel file of all the FDA new molecular entities between the years 1998 and July 2003, and new drug approvals between the years 1990 and 2002. See http://www.rsc.org/suppdata/ob/b3/b310752n/
25. Investigating peptide sequence variations for ‘double-click’ stapled p53 peptides.
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