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A simple and metal-free strategy for the regioselective synthesis of 1-N-substituted 1,2,3-triazole-4-carboxamide derivatives was developed by employing azides, HFO-1233zd(E) and amines in an aqueous reaction medium.

The development of modular, chemically diverse and regioselective reactions for expanding the cycloaddition reaction toolbox hinges heavily on a strict functional 1,3-dipole and dipolarophile pairing exploration. In this study, we...

An efficient, TFA-promoted cascade annulation of sulfur ylides, 2-hydroxy-β-nitrostyrenes and indoles was established. This reaction results in the construction of a diverse set of fluorescent benzofuro[3,2-b]carbazoles with the generation of seven new bonds and two new rings in a one-pot transformation. A plausible mechanism for this reaction was proposed. Moreover, the photo-physical properties of the benzofuro[3,2-b]carbazoles were observed to be simply tuned by changing the electronic nature of the peripheral substituents in the core.

Transition metal-free oxidative coupling of vinyl azides with sulfonyl hydrazines is described. This radical process realized oxidative multi-functionalization of vinyl azides in the presence of potassium iodide and t-butyl hydroperoxide, selectively yielding β-keto sulfones and α-halo-β-keto sulfones in good to excellent yields with a wide tolerance of functional groups.