1. Amplisins A–E, chromone methide polymers with hypoglycemic activity from a new fungicolous fungus Amplistroma fungicola
- Author
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Hongwei Liu, Xue Zhang, Jinjin Zhang, Lei Cai, Mengmeng Wang, Shenglong Wei, Baosong Chen, Huanqin Dai, and Junjie Han
- Subjects
chemistry.chemical_classification ,biology ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Glucose uptake ,Organic Chemistry ,Amplistroma ,Stimulation ,Polymer ,Fungus ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Biosynthesis ,Hepg2 cells ,Chromone - Abstract
Five new chromone methide polymers, (±)-amplisins A–D (1–4) and amplisin E (5), were isolated from a new fungicolous fungus Amplistroma fungicola. Compounds 1–5 were determined to have unusual chemical skeletons with two or three chromone methide groups linked with different polyketides. A non-enzymatic 1,4-Michael addition of chromone methide was verified in the biosynthesis of 1–5. Compounds 1 and 2 showed inhibition of PTP1B and stimulation of glucose uptake in insulin-resistant HepG2 cells. Compounds 3–5 exhibited strong NO inhibition of LPS-activated macrophages.
- Published
- 2020
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