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Your search keyword '"Scott, Peter"' showing total 3 results
3 results on '"Scott, Peter"'

1. Copper(II)-Mediated [ 11 C]Cyanation of Arylboronic Acids and Arylstannanes.

Author

Makaravage KJ, Shao X, Brooks AF, Yang L, Sanford MS, and Scott PJH

Subjects
Carbon Radioisotopes, Catalysis, Copper, Molecular Structure, Nitriles, Boronic Acids chemistry, Tin Compounds chemistry
Abstract

A copper-mediated method for the transformation of diverse arylboron compounds and arylstannanes to aryl-[ 11 C]-nitriles is reported. This method is operationally simple, uses commercially available reagents, and is compatible with a wide variety of substituted aryl- and heteroaryl substrates. This method is applied to the automated synthesis of high specific activity [ 11 C]perampanel in 10% nondecay-corrected radiochemical yield (RCY).

Published
2018
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2. Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids.

Author

Mossine AV, Brooks AF, Makaravage KJ, Miller JM, Ichiishi N, Sanford MS, and Scott PJ

Subjects
Catalysis, Molecular Structure, Nitriles chemistry, Positron-Emission Tomography, Pyridines chemistry, Radiopharmaceuticals chemistry, Boronic Acids chemistry, Copper chemistry, Fluorine Radioisotopes chemistry, Nitriles chemical synthesis, Pyridines chemical synthesis, Radiopharmaceuticals chemical synthesis
Abstract

A copper-mediated radiofluorination of aryl- and vinylboronic acids with K(18)F is described. This method exhibits high functional group tolerance and is effective for the radiofluorination of a range of electron-deficient, -neutral, and -rich aryl-, heteroaryl-, and vinylboronic acids. This method has been applied to the synthesis of [(18)F]FPEB, a PET radiotracer for quantifying metabotropic glutamate 5 receptors.

Published
2015
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3. Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids.

Author

Mossine, Andrew V., Brooks, Allen F., Makaravage, Katarina J., Miller, Jason M., Naoko Ichiishi, Sanford, Melanie S., and Scott, Peter J. H.

Subjects
*AROMATIC compound synthesis, *COPPER compounds, *FLUORINATION, *BORONIC acids, *GLUTAMATE receptors
Abstract

A copper-mediated radiofluorination of aryl- and vinylboronic acids with K18F is described. This method exhibits high functional group tolerance and is effective for the radiofluorination of a range of electron-deficient, -neutral, and -rich aryl-, heteroaryl-, and vinylboronic acids. This method has been applied to the synthesis of [18F]FPEB, a PET radiotracer for quantifying metabotropic glutamate 5 receptors. [ABSTRACT FROM AUTHOR]

Published
2015
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