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Your search keyword '"Zhao, Wenyi"' showing total 3 results
Start Over Author "Zhao, Wenyi" Journal organic letters Publisher american chemical society
3 results on '"Zhao, Wenyi"'

1. A Highly Concise and Convergent Synthesis of HCV PolymeraseInhibitor Deleobuvir (BI 207127): Application of a One-Pot Borylation–SuzukiCoupling Reaction.

Author

Zhang, Yongda, Lu, Bruce Z., Li, Guisheng, Rodriguez, Sonia, Tan, Jonathan, Wei, Han-Xun, Liu, Jianxiu, Roschangar, Frank, Ding, Fei, Zhao, Wenyi, Qu, Bo, Reeves, Diana, Grinberg, Nelu, Lee, Heewon, Heckmann, Golo, Niemeier, Oliver, Brenner, Michael, Tsantrizos, Youla, Beaulieu, Pierre L., and Hossain, Azad

Published
2014
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2. A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127): application of a one-pot borylation-Suzuki coupling reaction.

Author

Zhang Y, Lu BZ, Li G, Rodriguez S, Tan J, Wei HX, Liu J, Roschangar F, Ding F, Zhao W, Qu B, Reeves D, Grinberg N, Lee H, Heckmann G, Niemeier O, Brenner M, Tsantrizos Y, Beaulieu PL, Hossain A, Yee N, Farina V, and Senanayake CH

Subjects
Acrylates chemistry, Antiviral Agents chemistry, Benzimidazoles chemistry, Catalysis, Hepacivirus drug effects, Hepacivirus enzymology, Ligands, Molecular Structure, Palladium chemistry, Acrylates chemical synthesis, Acrylates pharmacology, Antiviral Agents chemical synthesis, Antiviral Agents pharmacology, Benzimidazoles chemical synthesis, Benzimidazoles pharmacology
Abstract

A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127, 1) was achieved, featuring efficient Pd-catalyzed one-pot borylation-Suzuki coupling where TFP was identified as the unique ligand effective for these transformations.

Published
2014
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3. A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions.

Author

Lu BZ, Zhao W, Wei HX, Dufour M, Farina V, and Senanayake CH

Subjects
Catalysis, Molecular Structure, Palladium chemistry, Combinatorial Chemistry Techniques, Indoles chemical synthesis
Abstract

[Structure: see text] A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.

Published
2006
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