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2. Synthesis and Biological Evaluation of Bicyclo[1.1.1]pentane-Containing Aromatic Lipoxin A

Author

Benjamin, Owen, Monica, de Gaetano, Andrew, Gaffney, Catherine, Godson, and Patrick J, Guiry

Subjects
Inflammation, Lipoxins, Pentanes, Anti-Inflammatory Agents, Humans
Abstract

Lipoxins are important drivers of inflammation resolution, suggesting a potential therapeutic benefit. Bicyclo[1.1.1]pentanes (BCPs) are potential isosteric replacements for arenes and/or alkyl groups within drug candidates. We carried out an asymmetric synthesis of four BCP-containing synthetic lipoxin A

Published
2022

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