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Your search keyword '"Cao, Zheng-Yu"' showing total 5 results
Start Over Author "Cao, Zheng-Yu" Journal organic letters
5 results on '"Cao, Zheng-Yu"'

1. Hypeisoxazole A, a Racemic Pair of Tetrahydroisoxazole-Fused Benzylisoquinoline Alkaloids from Hypecoum erectum and Structural Revision of Hypecoleptopine

Author

Sun, Pan-Ting, primary, Cao, Yan-Gang, additional, Xue, Gui-Min, additional, Li, Meng, additional, Zhang, Chun-Lei, additional, Zhao, Fang, additional, Cao, Zheng-Yu, additional, Wang, Dongdong, additional, Gustafson, Kirk R., additional, Zheng, Xiao-Ke, additional, Feng, Wei-Sheng, additional, and Chen, Hui, additional

Published
2022
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3. Hypeisoxazole A, a Racemic Pair of Tetrahydroisoxazole-Fused Benzylisoquinoline Alkaloids from Hypecoum erectumand Structural Revision of Hypecoleptopine

Author

Sun, Pan-Ting, Cao, Yan-Gang, Xue, Gui-Min, Li, Meng, Zhang, Chun-Lei, Zhao, Fang, Cao, Zheng-Yu, Wang, Dongdong, Gustafson, Kirk R., Zheng, Xiao-Ke, Feng, Wei-Sheng, and Chen, Hui

Abstract

(±)-Hypeisoxazole A (1), a racemic pair of rearranged benzylisoquinoline alkaloids possessing an unprecedented diindeno[2,1-c:2′,1′-d] isoxazole scaffold, was isolated from the medicinal herb Hypecoum erectum, along with hypecoleptopine (2), whose structure is now revised as a novel spiro-benzylisoquinoline alkaloid with a 6/6/5/6/6 skeleton. Their structures were determined by comprehensive spectroscopic and spectrometric analyses, X-ray diffraction, and computational studies. Racemic mixture of 2and its pure enantiomers modulated neuronal excitability activity.

Published
2022
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4. Alternarin A, a Drimane Meroterpenoid, Suppresses Neuronal Excitability from the Coral-Associated Fungi Alternariasp. ZH-15

Author

Wang, Hong-Liang, Li, Ran, Li, Jiao, He, Jing, Cao, Zheng-Yu, Kurtán, Tibor, Mándi, Attila, Zheng, Gui-Liang, and Zhang, Wen

Abstract

Alternarin A (1), a rearranged drimane meroterpenoid characterized by a thioglycerate moiety, was isolated together with two known analogues from the coral-associated fungi Alternariasp. ZH-15. Its structure was determined based on spectroscopic analysis, modified Mosher’s method, and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, compound 1effectively inhibited the activity of spontaneous synchronous Ca2+oscillations and 4-aminopyridine induced epileptic discharges in the low micromolar concentration range.

Published
2020
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