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11 results on '"Dake, Gregory R."'

10. Chiral phosphaalkene-oxazoline ligands for the palladium-catalyzed asymmetric allylic alkylation.

Author

Dugal-Tessier J, Dake GR, and Gates DP

Subjects
Alkylation, Catalysis, Ligands, Models, Molecular, Molecular Structure, Stereoisomerism, Alkenes chemistry, Allyl Compounds chemistry, Oxazoles chemistry, Palladium chemistry, Phosphates chemistry
Abstract

Enantioselective catalysis in moderate to excellent yields and ee's has been accomplished using a phosphaalkene-based ligand system. Specifically, the palladium-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate using a chiral P(sp(2)),N(sp(2)) ligand proceeds with a variety of malonate nucleophiles in 73-95% yield (79-92% ee).

Published
2010
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11. Platinum(II)-catalyzed cyclizations forming quaternary carbon centers, using enesulfonamides, enecarbamates, or enamides as nucleophiles.

Author

Harrison TJ, Patrick BO, and Dake GR

Subjects
Alkenes chemistry, Carbon chemistry, Catalysis, Cyclization, Molecular Structure, Stereoisomerism, Alkenes chemical synthesis, Alkynes chemistry, Amides chemistry, Carbamates chemistry, Platinum Compounds chemistry
Abstract

Cyclic enesulfonamides, enecarbamates, or enamides tethered to an alkyne cyclize readily with use of platinum(II) chloride. This reaction generates quaternary-substituted carbon centers within simple spiro-fused or more complex tri- and tetracyclic heterocyclic ring systems. The yields for this process range from 50% to 83%. [reaction: see text].

Published
2007
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