1. Spirocurcasone, a diterpenoid with a novel carbon skeleton from Jatropha curcas
- Author
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Heinz C. Schröder, Olapeju O. Aiyelaagbe, Paolo Luciano, Werner E.G. Müller, Giuseppina Chianese, Orazio Taglialatela-Scafati, Ernesto Fattorusso, Chianese, Giuseppina, Fattorusso, Ernesto, O. O., Aiyelaagbe, Luciano, Paolo, H. C., Schroder, W. E., Muller, and TAGLIALATELA SCAFATI, Orazio
- Subjects
biology ,Plant roots ,Molecular Structure ,Chemistry ,Mouse Lymphoma ,Organic Chemistry ,Carbon skeleton ,Jatropha ,biology.organism_classification ,Biochemistry ,Antineoplastic Agents, Phytogenic ,Plant Roots ,Terpenoid ,Mice ,Plant Bark ,Organic chemistry ,Animals ,Physical and Theoretical Chemistry ,Diterpenes ,Drug Screening Assays, Antitumor ,Jatropha curcas ,Spirocurcasone - Abstract
Spirocurcasone (14), a diterpenoid possessing the unprecedented "spirorhamnofolane" skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse lymphoma cell line.
- Published
- 2010