1. Palladium-Catalyzed Allyl–Allyl Reductive Coupling of Allylamines or Allylic Alcohols with H2 as Sole Reductant
- Author
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Xibing Zhou, Renbin Huang, Guoying Zhang, and Hanmin Huang
- Subjects
Allylic rearrangement ,010405 organic chemistry ,organic chemicals ,Organic Chemistry ,food and beverages ,chemistry.chemical_element ,Bond formation ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,Coupling reaction ,0104 chemical sciences ,Catalysis ,Coupling (electronics) ,chemistry ,Catalytic cycle ,Physical and Theoretical Chemistry ,Palladium - Abstract
Catalytic carbon-carbon bond formation building on reductive coupling is a powerful method for the preparation of organic compounds. The identification of environmentally benign reductants is key for establishing an efficient reductive coupling reaction. Herein an efficient strategy enabling H2 as the sole reductant for the palladium-catalyzed allyl-allyl reductive coupling reaction is described. A wide range of allylamines and allylic alcohols as well as allylic ethers proceed smoothly to deliver the C-C coupling products under 1 atm of H2. Kinetic studies suggested that the dinuclear palladium species was involved in the catalytic cycle.
- Published
- 2021