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Start Over Author "Jiakang Chen" Journal organic letters
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2. Divinylsulfonamides as Specific Linkers for Stapling Disulfide Bonds in Peptides

Author

Hongli Chen, Xianhao Zhou, Biao Jiang, Zhihong Li, Hongtao Xu, Rong Huang, Yuexiong Zhan, and Jiakang Chen

Subjects
Sulfonamides, Bioconjugation, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Disulfide bond, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, PEGylation, Posttranslational modification, Molecule, Disulfides, Physical and Theoretical Chemistry, Peptides
Abstract

A new class of N-phenyl-divinylsulfonamides which can be easily prepared have been successfully developed and utilized as efficient linkers in the field of disulfide bond modification. Functional divinylsulfonamides provide opportunities for the specific introduction of various functionalities, including affinity probes, fluorescent tags, and drugs, into peptides.

Published
2017

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