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5. Relative Configuration of JBIR-129, a Cytotoxic 34-Membered Glycosidic Polyol Macrolide from Streptomycessp. RK74.

Author

Kawahara, Teppei, Izumikawa, Miho, Takagi, Motoki, and Shin-ya, Kazuo

Subjects
*MACROLIDE antibiotics, *STREPTOMYCES, *NUCLEAR magnetic resonance spectroscopy, *AGLYCONES, *SUGAR, *ANTINEOPLASTIC antibiotics, *DRUG synergism
Abstract

JBIR-129 was isolated as the potent cytotoxic compound, which consists of the 34-membered polyol macrolide skeleton with five sugar moieties. The relative configuration of the aglycone moiety (C7–C27 and C33–C39) was established by the J-based configuration analysis using vicinal 1H–1H (from 1H NMR and PS-DQF-COSY spectra) and long-range 1H–13C coupling constants (from sge-HETLOC and several J-resolved HMBC spectra) with steric information obtained from ROESY. [ABSTRACT FROM AUTHOR]

Published
2012
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