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Start Over Author "Li, Yufei" Journal organic letters
7 results on '"Li, Yufei"'

7. (Fluoromethylsulfonyl)methylation of Quinoxalinones Using NaSO 2 CH 2 F for C-F Bond Cleavage.

Author

Dai P, Li Y, Chen Y, Jiao J, Wang Q, Li C, Gu Y, Zhang Y, Xia Q, and Zhang WH

Abstract

We developed a facile, efficient, and scalable route to achieve monofluoromethylsulfinyl alkylation of quinoxalinones. NaSO 2 CH 2 F served as the source of methylene to construct new C-C and C-S bonds via C-F bond cleavage. NaSO 2 CH 2 F was also the source of SO 2 CH 2 F. Density functional theory calculations confirmed the proposed mechanism, in which the SO 2 CH 2 F radical is immediately trapped. The reaction exhibited a high level of atom economy. Moreover, some representative products displayed excellent biological activity.

Published
2022
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