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Your search keyword '"Liu, Quan‐Zhong"' showing total 16 results
Start Over Author "Liu, Quan‐Zhong" Journal organic letters
16 results on '"Liu, Quan‐Zhong"'

8. Cyclization of Vinyl Diazo Compounds with Benzofuran-Derived Azadienes Enabled by NaBArF4

Author

Yang, Ting, Jiang, Qin, Wang, Chun-Mei, Li, Song-Liang, He, Cheng-Yu, Chu, Wen-Dao, and Liu, Quan-Zhong

Abstract

An unprecedented cycloaddition of vinyl diazo compounds with benzofuran-derived azadienes catalyzed by rarely independently used NaBArF4has been established. Benzofuran-fused hydropyridines were constructed with excellent yields and high diastereoselectivity via a Na+-catalyzed inverse-electron-demand aza-Diels–Alder reaction. Notably, this transformation also features good compatibility with a one-pot protocol to deliver the spiro[benzofuran-cyclopentene] skeleton, as well as perfect atom economy and simple reaction conditions.

Published
2023
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15. Synthesis of Cyclopenta[ b ]indoles via Sc(III)-Catalyzed Annulation of Vinyl Diazoacetates with Indole-Derived Unsaturated Imines.

Author

Jiang Q, Yang T, Li Q, Liang GM, Liu Y, He CY, Chu WD, and Liu QZ

Abstract

A Lewis acid Sc(OTf) 3 -catalyzed annulation reaction of vinyl diazoacetates with in situ formed α,β-unsaturated imines for the preparation of indole-fused tricyclic rings has been reported. This strategy involves a sequential addition/rebound addition process of vinyl diazoacetates and an in situ dedinitrogenation. This annulation protocol features low-cost catalysts, mild reaction conditions, and facilely prepared substrates.

Published
2023
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16. Palladium-catalyzed asymmetric cycloadditions of vinylcyclopropanes and in situ formed unsaturated imines: construction of structurally and optically enriched spiroindolenines.

Author

Liu ZS, Li WK, Kang TR, He L, and Liu QZ

Subjects
Catalysis, Cycloaddition Reaction, Imines chemistry, Molecular Structure, Spiro Compounds chemistry, Stereoisomerism, Cyclopropanes chemistry, Imines chemical synthesis, Indoles chemical synthesis, Indoles chemistry, Palladium chemistry, Spiro Compounds chemical synthesis, Sulfones chemistry, Vinyl Compounds chemistry
Abstract

A palladium-catalyzed (3 + 2) cycloaddition of vinyl cyclopropane and α,β-unsaturated imines generated in situ from aryl sulfonyl indoles is reported. The reaction proceeds with high diastereoselectivity to provide the optically enriched spirocyclopentane-1,3'-indolenines in up to 74% yield and with up to 97% ee, which contains an all-carbon quaternary center and two tertiary stereocenters. The reaction involves a first conjugate addition of the carbon anion of zwitterionic π-allylpalladium complex from vinyl cyclopropane to the in situ formed unsaturated imine followed by a palladium-catalyzed intramolecular C3-allylation of indole.

Published
2015
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