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Herein, we present a regioselective Pd-catalyzed C-H [4 + 2] benzannulation of N -unprotected 3-arylindoles with external readily available 1,3-dienes via an original sequence involving a Pd-catalyzed domino carbopalladation of 1,3-dienes/direct C 2 -H allylation of an indole ring followed by an oxidation or reduction step. Depending on the nature of the solvent, DCE or CH 3 CN, two consecutive approaches, oxidative or reductive, have been validated and applied to the design of a novel library of C 6 -alkyl or ( E )-C 6 -styryl-benzo[ c ]carbazoles in moderate to good yields.

This work reports a simple and efficient method for the direct phosphorylation of enamide under metal-free conditions. The P-centered radicals, derived from secondary phosphine oxides, are generated under mild reaction conditions in the presence of diphenyliodonium salt and Et 3 N and are introduced onto a range of enamides in good isolated yields. The method features broad substrate scope, good functional group tolerance, and efficient scale-up.