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Your search keyword '"Pei, T."' showing total 4 results
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4 results on '"Pei, T."'

1. Palladium-Catalyzed Intramolecular Hydroalkylation of Unactivated Olefins with Dialkyl Ketones

Author

Wang, X., Pei, T., Han, X., and Widenhoefer, R. A.

Abstract

Treatment of 3-butenyl heptyl ketone with substoichiometric amounts of PdCl2(CH3CN)2 (10 mol %), HCl (0.1 equiv), and CuCl2 (0.3 equiv) in dioxane at 70 °C for 12 h in a sealed tube formed 2-hexylcyclohexanone in 77% isolated yield. A number of alkyl 3-butenyl ketones underwent hydroalkylation under these conditions to form 2-substituted cyclohexanones in moderate to good yield.

Published
2003

2. Use of Pentamethyldisiloxane in the Palladium-Catalyzed Cyclization/Hydrosilylation of Functionalized Dienes

Author

Pei, T. and Widenhoefer, R. A.

Abstract

Pentamethyldisiloxane reacts with a range of functionalized dienes in the presence of a catalytic 1:1 mixture of (N−N)Pd(Me)Cl [N−N = 1,10-phenanthroline or (R)-(+)-4-isopropyl-2-(2-pyridinyl)-2-oxazoline] and NaBAr4 [Ar = 3,5-C6H3(CF3)2] to form the corresponding silylated carbocycles in good yield and with good stereoselectivity. Treatment of these silylated carbocycles with excess KF and peracetic acid at room temperature for 48 h formed the corresponding alcohols in excellent yield with retention of stereochemistry.

Published
2000

3. Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172.

Author

Kuethe J, Zhong YL, Yasuda N, Beutner G, Linn K, Kim M, Marcune B, Dreher SD, Humphrey G, and Pei T

Subjects
Amides, Antiviral Agents chemistry, Carbamates, Cyclopropanes, Macrocyclic Compounds chemistry, Molecular Structure, Protease Inhibitors chemistry, Quinoxalines chemistry, Sulfonamides, Antiviral Agents chemical synthesis, Antiviral Agents pharmacology, Hepacivirus drug effects, Macrocyclic Compounds chemical synthesis, Macrocyclic Compounds pharmacology, Protease Inhibitors chemical synthesis, Protease Inhibitors pharmacology, Quinoxalines chemical synthesis, Quinoxalines pharmacology
Abstract

The development of a practical, asymmetric synthesis of the hepatitis C virus (HCV) protease inhibitor MK-5172 (1), an 18-membered macrocycle, is described.

Published
2013
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4. Controlled synthesis of 2- and 3-substituted benzo[b]furans.

Author

Pei T, Chen CY, DiMichele L, and Davies IW

Subjects
Cyclization, Molecular Structure, Benzofurans chemical synthesis
Abstract

A controlled regioselective synthesis of either C-2 or C-3 substituted benzo[b]furans from readily accessible 1-(2-hydroxyphenyl)-2-chloroethanones is described. Addition of a range of Grignard reagents to the α-chloro ketones generates alkoxide intermediates, which can form either 2-substituted benzo[b]furans via a [1,2]-aryl migration or 3-substituted benzo[b]furans via a direct cyclization and dehydration sequence. A temperature-dependent [1,2]-aryl migration mechanism for the formation of 2-substituted benzo[b]furan is proposed.

Published
2010
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