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Your search keyword '"Polycyclic Sesquiterpenes isolation & purification"' showing total 2 results
Start Over Descriptor "Polycyclic Sesquiterpenes isolation & purification" Journal organic letters
2 results on '"Polycyclic Sesquiterpenes isolation & purification"'

1. Alternarin A, a Drimane Meroterpenoid, Suppresses Neuronal Excitability from the Coral-Associated Fungi Alternaria sp. ZH-15.

Author

Wang HL, Li R, Li J, He J, Cao ZY, Kurtán T, Mándi A, Zheng GL, and Zhang W

Subjects
Agaricales, Animals, Density Functional Theory, Molecular Conformation, Polycyclic Sesquiterpenes chemistry, Polycyclic Sesquiterpenes isolation & purification, Alternaria chemistry, Calcium metabolism, Polycyclic Sesquiterpenes pharmacology
Abstract

Alternarin A ( 1 ), a rearranged drimane meroterpenoid characterized by a thioglycerate moiety, was isolated together with two known analogues from the coral-associated fungi Alternaria sp. ZH-15. Its structure was determined based on spectroscopic analysis, modified Mosher's method, and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, compound 1 effectively inhibited the activity of spontaneous synchronous Ca 2+ oscillations and 4-aminopyridine induced epileptic discharges in the low micromolar concentration range.

Published
2020
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2. Curcumanes A and B, Two Bicyclic Sesquiterpenoids with Significant Vasorelaxant Activity from Curcuma longa.

Author

Liu Y, Liu F, Qiao MM, Guo L, Chen MH, Peng C, and Xiong L

Subjects
Animals, Calcium Channel Blockers chemistry, Calcium Channel Blockers isolation & purification, Polycyclic Sesquiterpenes chemistry, Polycyclic Sesquiterpenes isolation & purification, Rats, Receptors, Calcium-Sensing metabolism, Vasodilator Agents chemistry, Vasodilator Agents isolation & purification, Aorta, Thoracic drug effects, Calcium Channel Blockers pharmacology, Calcium Channels metabolism, Curcuma chemistry, Polycyclic Sesquiterpenes pharmacology, Receptors, Calcium-Sensing antagonists & inhibitors, Vasodilator Agents pharmacology
Abstract

Two novel sesquiterpenoids, curcumanes A (1) and B (2), possessing unprecedented skeletons with a dicyclo[3.2.1]octane and a dicyclo[3.3.1]nonane moiety, respectively, were isolated from Curcuma longa. Both of them had remarkable vasorelaxant activity on rat aorta via blocking extracellular Ca 2+ influx through VDCCs and ROCCs. The activity of 1 was endothelium-independent, while that of 2 was endothelium-dependent. Compound 2 also prolonged APTT and TT to inhibit blood coagulation.

Published
2019
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