1. Novel cyclic hexapeptides from marine-derived fungus, Aspergillus sclerotiorum PT06-1
- Author
-
Jinkai Zheng, Kui Hong, Yi Wang, Xin Wang, Huajie Zhu, Xiaoping Peng, Peipei Liu, and Weiming Zhu
- Subjects
Models, Molecular ,Staphylococcus aureus ,Antifungal Agents ,Photoisomerization ,Stereochemistry ,Radical ,Molecular Conformation ,Stereoisomerism ,Antineoplastic Agents ,HL-60 Cells ,Microbial Sensitivity Tests ,Crystallography, X-Ray ,Biochemistry ,Peptides, Cyclic ,chemistry.chemical_compound ,Structure-Activity Relationship ,Candida albicans ,Anthranilic acid ,Escherichia coli ,Structure–activity relationship ,Humans ,Physical and Theoretical Chemistry ,Cytotoxicity ,Cell Proliferation ,Organic Chemistry ,Enterobacter aerogenes ,Anti-Bacterial Agents ,Aspergillus ,chemistry ,Pseudomonas aeruginosa ,Halotolerance ,Drug Screening Assays, Antitumor ,Antibacterial activity ,Bacillus subtilis - Abstract
Two novel cyclic hexapeptides containing both anthranilic acid and dehydroamino acid units, sclerotides A (1) and B (2), were isolated from the marine-derived halotolerant Aspergillus sclerotiorum PT06-1 in a nutrient-limited hypersaline medium. Both 1 and 2 are photointerconvertible and could be interconverted via a radical reaction initiated by direct photoisomerization. Both compounds showed moderate antifungal activity. Compound 2 also showed weak cytotoxicity and antibacterial activity.
- Published
- 2009