1. Lycoplanine A, a C16N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum
- Author
-
Qin-Shi Zhao, Xiao-Nian Li, Jia Su, Jian Yang, Zhi-Jun Zhang, Yin Nian, Xing-De Wu, and Qin-Feng Zhu
- Subjects
chemistry.chemical_classification ,Lycopodium ,biology ,010405 organic chemistry ,Dodecane ,Stereochemistry ,Organic Chemistry ,Absolute configuration ,010402 general chemistry ,biology.organism_classification ,Ring (chemistry) ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Moiety ,Physical and Theoretical Chemistry ,Nonane ,Lycopodium alkaloid ,Tricyclic - Abstract
Lycoplanine A (1), a Lycopodium alkaloid with a 6/9/5 tricyclic ring skeleton fused with the γ-lactone ring and featuring an unusual 1-oxa-6-azaspiro[4.4]nonane moiety and an unprecedented 3-azabicyclo[6.3.1]dodecane unit, was isolated from the club moss Lycopodium complanatum. The structure and absolute configuration of 1 were identified by a combination of NMR spectroscopic analysis and single-crystal X-ray diffraction. Biological studies showed that 1 is a potent Cav3.1 T-type calcium channel (TTCC) inhibitor with an IC50 value of 6.06 μM.
- Published
- 2017