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2 results on '"Yu-Ting Hsu"'

1. Overcoming the drug resistance in breast cancer cells by rational design of efficient glutathione S-transferase inhibitors

Author

Hui Chuan Chang, Wing See Lam, Kung-Cheng Liu, Sachin S. Shivatare, Ya Ching Jen, Yu-Ting Hsu, Wen-Shan Li, Shu-Chuan Jao, and Chie-Hong Wang

Subjects
Models, Molecular, Activity profile, biology, Organic Chemistry, Rational design, Breast Neoplasms, Drug resistance, Pharmacology, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Glutathione S-transferase, chemistry, Chemotherapy Drugs, Drug Resistance, Neoplasm, Drug Design, biology.protein, Humans, Female, Breast cancer cells, Bioisostere, Physical and Theoretical Chemistry, Glutathione Transferase
Abstract

A new type of competitive human GST inhibitors has been developed via the bioisostere and structure activity profile strategies; we report their discovery, preparation, inhibitory activity, and synergetic effect in combination with chemotherapy drugs against breast cancer cells.

Published
2009

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