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Your search keyword '"Zhang, Xing-Jie"' showing total 4 results
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4 results on '"Zhang, Xing-Jie"'

2. Premnafulvol A: A Diterpenoid with a 6/5/7/3-Fused Tetracyclic Core and Its Biosynthetically Related Analogues from Premna fulva

Author

Pu, De-Bing, primary, Du, Bao-Wen, additional, Chen, Wen, additional, Gao, Jun-Bo, additional, Hu, Kun, additional, Shi, Nan, additional, Li, Yi-Ming, additional, Zhang, Xing-Jie, additional, Zhang, Rui-Han, additional, Li, Xiao-Nian, additional, Zhang, Hong-Bin, additional, Wang, Fei, additional, and Xiao, Wei-Lie, additional

Published
2018
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4. Euphopias A-C: Three Rearranged Jatrophane Diterpenoids with Tricyclo[8.3.0.0 2,7 ]tridecane and Tetracyclo[11.3.0.0 2,10 .0 3,7 ]hexadecane Cores from Euphorbia helioscopia .

Author

Shi QQ, Zhang XJ, Wang TT, Wang Q, Sun TT, Amin M, Zhang RH, Li XL, and Xiao WL

Subjects
Alkanes chemistry, Diterpenes chemistry, Diterpenes isolation & purification, Molecular Structure, NLR Family, Pyrin Domain-Containing 3 Protein chemistry, Diterpenes pharmacology, Euphorbia chemistry, NLR Family, Pyrin Domain-Containing 3 Protein antagonists & inhibitors
Abstract

Euphopias A-C ( 1 - 3 ), three rearranged jatrophane-type diterpenoids with tricyclo[8.3.0.0 2,7 ]tridecane ( 1 and 2 ) and tetracyclo[11.3.0.0 2,10 .0 3,7 ]hexadecane ( 3 ) cores, were isolated from Euphorbia helioscopia . Comprehensive spectroscopic analyses, quantum-chemical calculations, and X-ray diffractions were used to identify their structures. Compounds 1 - 3 could significantly inhibit NLRP3 inflammasome activation and block NLRP3 inflammasome-induced pyroptosis. Additionally, a mechanistic study revealed that 2 could ameliorate mitochondria damage, thereby interrupting NLRP3 inflammasome activation.

Published
2020
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