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2 results on '"Zheng, Hai-Zhou"'

1. Penerpenes A–D, Four Indole Terpenoids with Potent Protein Tyrosine Phosphatase Inhibitory Activity from the Marine-Derived Fungus Penicillium sp. KFD28

Author

Kong, Fan-Dong, primary, Fan, Peng, additional, Zhou, Li-Man, additional, Ma, Qing-Yun, additional, Xie, Qing-Yi, additional, Zheng, Hai-Zhou, additional, Zheng, Zhi-Hui, additional, Zhang, Ren-Shuai, additional, Yuan, Jing-Zhe, additional, Dai, Hao-Fu, additional, Luo, Du-Qiang, additional, and Zhao, You-Xing, additional

Published
2019
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2. Penerpenes A–D, Four Indole Terpenoids with Potent Protein Tyrosine Phosphatase Inhibitory Activity from the Marine-Derived Fungus Penicilliumsp. KFD28

Author

Kong, Fan-Dong, Fan, Peng, Zhou, Li-Man, Ma, Qing-Yun, Xie, Qing-Yi, Zheng, Hai-Zhou, Zheng, Zhi-Hui, Zhang, Ren-Shuai, Yuan, Jing-Zhe, Dai, Hao-Fu, Luo, Du-Qiang, and Zhao, You-Xing

Abstract

Four unusual indole-terpenoids, penerpenes A–D (1–4), along with two known ones paxilline (5) and emindole SB (6), were isolated from the marine-derived fungus Penicilliumsp. KFD28. The absolute structures of 1–4were elucidated on the basis of spectroscopic data and ECD spectra analysis along with quantum ECD calculations. Compounds 1and 2showed potent inhibitory activity toward protein tyrosine phosphatases (PTP1B and TCPTP). Plausible biosynthetic pathways of compounds 1–4are proposed.

Published
2019
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