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Your search keyword '"Feng, Yahui"' showing total 10 results
Start Over Author "Feng, Yahui" Journal organic process research & development
10 results on '"Feng, Yahui"'

3. Development of a Synthesis Process for a Novel HCV NS5A Inhibitor, Emitasvir

Author

Yingjun Zhang, Enhuo Huang, Delie An, Xuwen Xiang, Feng Yahui, Hongming Xie, Wanrong Dong, Zhihong Peng, Haiwang Liu, and Fang Qinghong

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Process development, Stereochemistry, viruses, Hepatitis C virus, Organic Chemistry, Enantioselective synthesis, virus diseases, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Small molecule, Desymmetrization, digestive system diseases, 0104 chemical sciences, Enzyme, chemistry, medicine, HCV NS5A Inhibitor, Physical and Theoretical Chemistry, NS5A
Abstract

A new approach to the synthesis of Emitasvir (DAG181), a small molecule hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor, is described. Enantioselective enzymatic desymmetrization ...

Published
2021

4. Development of an Efficient and Scalable Biocatalytic Route to (1S,4R)-8-Hydroxy-1,2,3,4- tetrahydro-1,4-methanonaphthalen-5-yl Propionate via Enantioselective Enzymatic Desymmetrization of a Prochiral Diester

Author

Lei Zhang, Ridong Li, Hongming Xie, Zhonghua Luo, Zhongqing Wang, Feng Yahui, Zhenxiu Luo, Yingjun Zhang, and Lai Jinqiang

Subjects
chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, Enantioselective synthesis, 010402 general chemistry, 01 natural sciences, Desymmetrization, 0104 chemical sciences, Hydrolysis, Enzyme, chemistry, Propionate, Organic chemistry, Physical and Theoretical Chemistry
Abstract

An efficient procedure for enzymatic desymmetrization of the prochiral diphenol compound 2 was successfully developed to prepare the pharmaceutical intermediate (1S,4R)-8-hydroxy-1,2,3,4-tetrahydro...

Published
2019

5. Further Optimization of a Scalable Biocatalytic Route to (3R)-N-Boc-3-aminoazepane with Immobilized ω-Transaminase

Author

Fang He, Liu Bin, Zhongqing Wang, Feng Yahui, Chen Minghong, Lei Zhang, Siegfried Goldmann, and Zhonghua Luo

Subjects
Chromatography, Immobilized enzyme, Chemistry, Yield (chemistry), Organic Chemistry, Physical and Theoretical Chemistry, Transaminase, Process conditions
Abstract

An efficient method for the synthesis of (3R)-N-Boc-3-aminoazepane with immobilized ω-transaminase (ω-TA) has been further optimized. In comparison with the crude enzyme powder or wet whole cells, this immobilized enzyme exhibits excellent activity and stability under the optimum process conditions, allowing 20 rounds of enzyme reuse without obvious loss of activity. This procedure simplified the workup and was performed on a multikilogram scale in a reproducible manner to yield (3R)-N-Boc-3-aminoazepane with 99.2% ee and 97.0% purity.

Published
2019

7. Development of an Efficient and Scalable Biocatalytic Route to (3R)-3-Aminoazepane: A Pharmaceutically Important Intermediate

Author

Zhongqing Wang, Chen Minghong, Siegfried Goldmann, Lin Wei, Zhonghua Luo, Guodong Sun, Lai Jinqiang, Lei Zhang, and Feng Yahui

Subjects
010405 organic chemistry, Computer science, Organic Chemistry, Improved method, Nanotechnology, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Stereocenter, Yield (chemistry), Scalability, Metal catalyst, Physical and Theoretical Chemistry
Abstract

An efficient and novel route to (3R)-3-aminoazepane (1) is described. The target is obtained with 99.92% purity, 99.2% ee in seven steps, and 46.2% overall yield. This improved method involves a practical biocatalytic transformation with ω-transaminase to establish the stereogenic center high efficiently as a key step. The developed process was scalable, cost-effective, with a simplified reaction workup, avoiding the use of expensive metal catalyst or chromatography, and commercially viable for the synthesis of 1.

Published
2017

8. Development of an Efficient and Scalable Biocatalytic Route to (1S,4R)-8-Hydroxy-1,2,3,4- tetrahydro-1,4-methanonaphthalen-5-yl Propionate via Enantioselective Enzymatic Desymmetrization of a Prochiral Diester

Author

Feng, Yahui, primary, Wang, Zhongqing, additional, Luo, Zhonghua, additional, Lai, Jinqiang, additional, Xie, Hongming, additional, Luo, Zhenxiu, additional, Zhang, Lei, additional, Li, Ridong, additional, and Zhang, Yingjun, additional

Published
2019
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