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Your search keyword '"Paolo Ghetti"' showing total 3 results
Start Over Author "Paolo Ghetti" Journal organic process research & development
3 results on '"Paolo Ghetti"'

1. Polymorphisms and Patent, Market, and Legal Battles: Cefdinir Case Study

Author

Walter Cabri, Giovanni Pozzi, Paolo Ghetti, Marco Alpegiani, Cabri W, Ghetti P, Pozzi G, and Alpegiani M

Subjects
Battle, media_common.quotation_subject, Organic Chemistry, medicine, Business, Physical and Theoretical Chemistry, cefdinir, polymorphs, Cefdinir, media_common, medicine.drug, Law and economics
Abstract

The ongoing patent battle relating to Cefdinir polymorphism and crystalline forms is described from a scientific point of view. This case study illustrates some of the strategies adopted by generic bulk manufacturers to challenge originator's patents on polymorphic forms.

Published
2006
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2. Development of a Practical High-Yield Industrial Synthesis of Pergolide Mesylate

Author

Piera Fonte, Walter Cabri, Elio Mapelli, Paolo Paissoni, Simonetta Songia, Sara Olmo, Jacopo Roletto, Paolo Ghetti, and Marco Alpegiani

Subjects
Pergolide Mesylate, Chemistry, Stereochemistry, Yield (chemistry), Organic Chemistry, Organic chemistry, Physical and Theoretical Chemistry
Abstract

The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75−81% overall yield from dihydrolysergic acid 4 with >99.8% purity.

Published
2006
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