1. Mild and regioselective azol-halogenation of alkenes
- Author
-
Baixue Luan, Jiali Zhu, Enqi Bai, Zhenhua Liu, Kai Sun, Yu Fang, Jikang Du, and Bing Zhang
- Subjects
010405 organic chemistry ,Chemistry ,Organic Chemistry ,Substrate (chemistry) ,Regioselectivity ,Halogenation ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences ,chemistry.chemical_compound ,Nucleophile ,Functional group ,Physical and Theoretical Chemistry ,Derivatization ,Amine derivatives - Abstract
An economical and practical azol-halogenation protocol of alkenes, which provides a general approach to construct a series of structurally diverse β-halogenated amine derivatives, is reported. The wide substrate scope, good functional group tolerance, ease of large-scale preparation and potential for product derivatization make this reaction attractive. Mechanistic studies suggest that the azol-halogenation process might involve a radical halogenation followed by nucleophilic azolyation.
- Published
- 2019