1. Time‐of‐Day Predominance of Allergic Rhinitis Symptoms during Treatment with Intranasal Ciclesonide 200 mcg qd
- Author
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Maria del Carmen C. Salas, Jazmin Chiu Ugalde, Estefania Torres Medina, Juan Carlos Lopez Alvarenga, and Jose-Antonio Vargas
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Ciclesonide ,Nasal congestion ,Gastroenterology ,Confidence interval ,Basal (phylogenetics) ,chemistry.chemical_compound ,medicine.anatomical_structure ,Time of day ,Otorhinolaryngology ,chemistry ,Internal medicine ,medicine ,Surgery ,Nasal administration ,medicine.symptom ,business ,Nose ,Morning - Abstract
Objectives:(1) Effectiveness of intranasal ciclesonide 200 mcg qd (CIC). (2) Time-of-day predominance (TDP) of nasal and nonnasal AR symptoms. TDP is the main focus of this report.Methods:Phase IV, open-label, noninterventional study. Patients aged 12 years with at least a 2-year history of AR were eligible; 1526 patients with active AR were enrolled and received CIC during 4 weeks. TDP was recorded by patients and classified as: Morning, noon, afternoon, night or none. TDP was evaluated at T0 (basal), once daily during the first treatment-week, and once a week during the rest of the study (weeks 2 to 4). Relative frequencies of AR symptoms were calculated with corresponding 95% confidence intervals. Differences between basal TDP-relative frequency and at treatment-days 7 and 28, were calculated using z test.Results:All symptoms were of morning predominance at baseline, for example, runny nose 51%, nasal congestion 51%, sneezing 49%. Morning predominance remained the highest for all evaluated symptoms dur...
- Published
- 2014
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