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Objectives: To evaluate the procedural and short-term results of percutaneous atrial septal defect (ASD) closure in adults. Methodology: We retrospectively analysed 149 consecutive patients with a secundum ASD who underwent percutaneous closure from September 2011 to January 2021. Procedural and short-term results, including arrhythmia, device embolisation and residual shunt, were assessed at 2 days and 4 weeks and 6 months after percutaneous closure of atrial septal defect. Results: The patients were 14 to 77 (37.7 ± 15.0) years old and 101 (67.8%) were female. Maximum defect size was 18.0 ± 6.3 mm measured on transoesophageal echocardiography. The device diameter used in patients who underwent closure was 21.9 ± 6.9 mm (6-38 mm). Percutaneous closure procedure success rate was 93.3%. In our study, the rates of device embolisation, arrhythmia and residual shunt were 3.6%, 1.4%, and 2.2%, respectively. Conclusion: Transcatheter closure of ASDs in adults was feasible in our centre with good short-term outcome. The procedure should be performed in experienced centres by cardiologists specialised in the treatment of structural heart diseases due to potentially severe complications. [ABSTRACT FROM AUTHOR]

Objective: To find out correlation of age and defect size of isolated secundum atrial septal defect with pulmonary artery pressure measured by cardiac catheterization. Methodology: It was a cross-sectional study conducted at Cardiology department, Lady Reading Hospital, Peshawar from January 2012 to December 2016. Eligible patients were included in the study through cardiology out patient department. Patients with other causes of raised PAP were excluded. Diagnosis was made by transthoracic echocardiography while size of defect was measured with trans-esophageal echocardiography. Pulmonary artery pressures (PAP) were measured with right heart catheterization. The data was analyzed by SPSS 20. Correlation of age and ASD size with PAP groups were examined by Pearson correlation (2-tailed) and R value was calculated.Results:A total of 104 consecutive patients were included with 65.4 % of females. Mean age and defect size were 23.25 ± 12.2 years and 23.36 ± 5.81 mm, respectively. Average systolic and mean PAP were 37.88±12.3 and 24.48 ± 8.19 mmHg, respectively with 49 (47.1%) patients had raised PAP. Age and size were positively correlated with systolic (R=0.220 & 0.198) and mean PAP (R=0.288 & 0.218) respectively , with most significant results in second and third decade of life and defect size of>20mm(p <0.002). Conclusion:Age and ASD size were positively correlated with pulmonary artery pressure. Moreover PAP can be predicted by the age of patients with ASD secundum. [ABSTRACT FROM AUTHOR]