1. A decade of follow-up and therapeutic drug monitoring in HIV-2 immunocompromised patients at St Camille and General Lamizana Military Medical Centers, Burkina Faso, West Africa
- Author
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Jacques Simpore, R. Ouedraogo Traore, Bolni Marius Nagalo, Paul Ouedraogo, Cyrille Bisseye, F. Bationo, Mahamoudou Sanou, Théodora Mahoukèdè Zohoncon, Serge Théophile Soubeiga, Virginio Pietra, T. R. Compaore, and G. N. Diatto
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Time Factors ,Anti-HIV Agents ,HIV Infections ,Disease ,Opportunistic Infections ,Hospitals, Military ,Weight Gain ,Immunocompromised Host ,Acquired immunodeficiency syndrome (AIDS) ,Weight loss ,HIV Seroprevalence ,Pregnancy ,Burkina Faso ,medicine ,Prevalence ,Seroprevalence ,Humans ,Retrospective Studies ,business.industry ,Medical record ,virus diseases ,Middle Aged ,medicine.disease ,Surgery ,CD4 Lymphocyte Count ,Treatment Outcome ,HIV-2 ,Disease Progression ,HIV-1 ,Drug Therapy, Combination ,Female ,medicine.symptom ,Drug Monitoring ,business ,Agronomy and Crop Science ,Body mass index ,Viral load ,Shingles ,Follow-Up Studies - Abstract
Although, HIV-2 is generally less pathogenic than HIV-1 and its progression towards AIDS occurs less frequently. HIV-2 remains an important cause of disease in West Africa. This study aimed to evaluate HIV-1 and HIV-2 prevalence among pregnant women and to describe the demographic and clinical profile of patients with HIV-2 infection from 2003-2013 at St Camille and General Lamizana Military Medical Centers. A retrospective investigation was conducted using 12,287 medical records from patients screened for HIV. To respond to the lack of data available regarding HIV-2 treatment and also to address the approach to clinical, biological as well as therapeutic monitoring, 62 HIV-2 infected patients' medical records were studied. Seroprevalence of 10.6 and 0.14% were obtained, respectively for HIV-1 and HIV-2 among 12,287 women screened during the study period. From the sixty two (62) HIV-2 patients, the average age was 49.2 years (sex ratio was 0.65). The weight loss and diarrhea were the major clinical manifestations observed, respectively 54.8 and 25.8%. Fungi and herpes zoster (shingles) infections were reported as major opportunistic infections. Also, nearly half of the patients had more than 60 kg, less than 2% were in WHO stage IV and about 2/3 had a CD4 count bellow 250 cells mm(-3). AZT-3TC-IDV/LPV/R was the most prescribed combination. The gain in weight gain the Body Mass Index (BMI) improvement and the non-significant increase of the rate of CD4 between 1st (M1) and 24th month (M24) were observed after treatment with antiviral.
- Published
- 2015